PDF(Pubmed)
Abstract：
Chronic progressive lymphedema (CPL) in draft horses is characterized by increased dermal thickness and fibrosis, with the development of skinfolds and nodules, hyperkeratosis, and ulcerations on the distal limbs of affected horses. Secondary bacterial, fungal, or parasitic infections frequently complicate and aggravate the lesions, as well as the progression of this disease. CPL has a particularly high prevalence of up to 85.86% in the Belgian draft horse breed. Due to the disease\'s progressive and incurable nature, affected horses are often euthanized prematurely. The treatment options are solely symptomatic, aimed at improving the horse\'s quality of life. Despite the severity of this condition, many uncertainties about its etiology and pathogenesis still remain to date. The established scientific research on CPL is rather limited, although there is an urgent need for strategies to tackle this disease. This review summarizes the available knowledge, serving as a guideline for practitioners, and provides perspectives for future research programs.
摘要：
拔马的慢性进行性淋巴水肿（CPL）的特征是真皮厚度和纤维化增加，随着皮肤褶皱和结节的发展，角化过度,和患马远端肢体的溃疡。次级细菌,真菌,或寄生虫感染经常使病变复杂化和加重，以及这种疾病的进展。在比利时选马品种中，CPL的患病率特别高，高达85.86％。由于疾病的进行性和不可治愈的性质，受影响的马通常会过早安乐死。治疗选择仅是症状，旨在提高马的生活质量。尽管这种情况很严重，迄今为止，关于其病因和发病机制的许多不确定性仍然存在。关于CPL的既定科学研究相当有限，尽管迫切需要应对这种疾病的策略。这篇综述总结了现有的知识，作为从业者的指导方针，并为未来的研究计划提供了前景。
