PDF(Pubmed)
Abstract：
UNASSIGNED: Anisakiasis is a parasitic disease caused by the consumption of raw or undercooked fish that is infected with Anisakis third-stage larvae. In countries, such as Japan, Italy, and Spain, where people have a custom of eating raw or marinated fish, anisakiasis is a common infection. Although anisakiasis has been reported in the gastrointestinal tract in several countries, reports of anisakiasis accompanied by cancer are rare.
UNASSIGNED: We present the rare case of a 40-year-old male patient with anisakiasis coexisting with mucosal gastric cancer. Submucosal gastric cancer was suspected on gastric endoscopy and endoscopic ultrasonography. After laparoscopic distal gastrectomy, granulomatous inflammation with Anisakis larvae in the submucosa was pathologically revealed beneath mucosal tubular adenocarcinoma. Histological and immunohistochemical investigation showed cancer cells as intestinal absorptive-type cells that did not produce mucin.
UNASSIGNED: Anisakis larvae could have invaded the cancer cells selectively because of the lack of mucin in the cancerous epithelium. Anisakiasis coexisting with cancer is considered reasonable rather than coincidental. In cancer with anisakiasis, preoperative diagnosis may be difficult because anisakiasis leads to morphological changes in the cancer.
UNASSIGNED: We present the rare case of a 40-year-old male patient with anisakiasis coexisting with mucosal gastric cancer. Submucosal gastric cancer was suspected on gastric endoscopy and endoscopic ultrasonography. After laparoscopic distal gastrectomy, granulomatous inflammation with Anisakis larvae in the submucosa was pathologically revealed beneath mucosal tubular adenocarcinoma. Histological and immunohistochemical investigation showed cancer cells as intestinal absorptive-type cells that did not produce mucin.
UNASSIGNED: Anisakis larvae could have invaded the cancer cells selectively because of the lack of mucin in the cancerous epithelium. Anisakiasis coexisting with cancer is considered reasonable rather than coincidental. In cancer with anisakiasis, preoperative diagnosis may be difficult because anisakiasis leads to morphological changes in the cancer.
摘要：
■anisakiasis是一种寄生虫病，是由于食用生的或未煮熟的鱼而感染了anisakis第三期幼虫。在一些国家,比如日本,意大利,西班牙,人们有吃生鱼或腌鱼的习俗，茴香病是一种常见的感染。虽然在几个国家的胃肠道中已经报道了茴香病，伴有癌症的anisakiasis的报道很少见。
■我们介绍了一例罕见的40岁男性患者与粘膜胃癌并存。胃镜和内镜超声检查怀疑粘膜下胃癌。腹腔镜远端胃切除术后，在粘膜管状腺癌下方，病理上发现了粘膜下层带有Anisakis幼虫的肉芽肿性炎症。组织学和免疫组织化学研究显示癌细胞为不产生粘蛋白的肠吸收型细胞。
■异语幼虫可能由于癌上皮中缺乏粘蛋白而选择性地侵入了癌细胞。异株病与癌症共存被认为是合理的，而不是巧合。在患有茴香病的癌症中，术前诊断可能很困难，因为茴香病导致癌症的形态学变化。
■我们介绍了一例罕见的40岁男性患者与粘膜胃癌并存。胃镜和内镜超声检查怀疑粘膜下胃癌。腹腔镜远端胃切除术后，在粘膜管状腺癌下方，病理上发现了粘膜下层带有Anisakis幼虫的肉芽肿性炎症。组织学和免疫组织化学研究显示癌细胞为不产生粘蛋白的肠吸收型细胞。
■异语幼虫可能由于癌上皮中缺乏粘蛋白而选择性地侵入了癌细胞。异株病与癌症共存被认为是合理的，而不是巧合。在患有茴香病的癌症中，术前诊断可能很困难，因为茴香病导致癌症的形态学变化。
