PDF(Pubmed)
Abstract：
Ameloblastic carcinoma (AC) is a rare, primary epithelial odontogenic malignant neoplasm. It is the malignant counterpart of ameloblastoma. It comprises 1% of all cysts and tumours occurring in the jaws, arising from tissues associated with odontogenic epithelium. The objective of the present study was to describe a clinical case of a 63-year-old male with an enlargement in the mandible on the left side. Panoramic radiography revealed a radiolucent area with poorly defined borders, and an incisional biopsy was performed for the histopathological study using immunomarkers such as SOX2 and Ki-67. Ki-67 is considered a marker of cell proliferation, and SOX2 reportedly participates in the development of the ameloblastic epithelium lineage and is associated with a more aggressive clinical course. A final histopathological diagnosis of AC was given. Unfortunately, the patient died one week before surgical resection (the surgical treatment of choice for AC).
摘要：
成釉细胞癌（AC）是一种罕见的，原发性上皮牙源性恶性肿瘤。它是成釉细胞瘤的恶性对应物。它占颌骨所有囊肿和肿瘤的1%，来自与牙源性上皮相关的组织。本研究的目的是描述一名63岁男性的临床病例，其左侧下颌骨增大。全景射线照相术显示射线可透过的区域边界界定不清，并使用SOX2和Ki-67等免疫标志物进行组织病理学研究。Ki-67被认为是细胞增殖的标志物，据报道，SOX2参与成釉细胞上皮谱系的发育，并与更具侵略性的临床过程有关。给出AC的最终组织病理学诊断。不幸的是,患者在手术切除（AC的首选手术治疗）前一周死亡。
