PDF(Pubmed)
Abstract：
Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of macronutrients in the genome function and programming of the developing fetus. On the other hand, there is a paucity of knowledge about the role of micronutrients and, specifically, minerals in regulating the epigenome of livestock species, especially cattle. Therefore, this review will address the effects of the maternal dietary mineral supply on the fetal developmental programming from the embryonic to the postnatal phases in cattle. To this end, we will draw a parallel between findings from our cattle model research with data from model animals, cell lines, and other livestock species. The coordinated role and function of different mineral elements in feto-maternal genomic regulation underlies the establishment of pregnancy and organogenesis and, ultimately, affects the development and functioning of metabolically important tissues, such as the fetal liver, skeletal muscle, and, importantly, the placenta. Through this review, we will delineate the key regulatory pathways involved in fetal programming based on the dietary maternal mineral supply and its crosstalk with epigenomic regulation in cattle.
摘要：
在胎儿发育的关键时期，母亲的矿物质营养可能会对个体的生产力产生影响。健康与疾病（DOHaD）领域的发育起源中的大多数研究都集中在大量营养素在发育中的胎儿的基因组功能和编程中的作用。另一方面,对微量营养素的作用知之甚少，具体来说,调节家畜表观基因组的矿物质，尤其是牛。因此,这篇综述将讨论母牛膳食矿物质供应对从胚胎到出生后阶段胎儿发育程序的影响。为此,我们将得出牛模型研究的结果与模型动物的数据之间的相似之处，细胞系,和其他牲畜物种。不同矿质元素在母胎基因组调控中的协调作用和功能是建立妊娠和器官发生的基础，最终,影响代谢重要组织的发育和功能，比如胎儿肝脏，骨骼肌,and,重要的是,胎盘。通过这次审查,我们将根据母牛的膳食矿物质供应及其与表观基因组调控的串扰，描述胎儿编程中涉及的关键调控途径。
