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Abstract：
Along with the improvement of lung cancer screening implementation, the identification of interstitial lung abnormality (ILA) is increasing. Currently, there is a limited description of the oncogenic status and ILA subtypes among newly diagnosed non-small cell lung cancer (NSCLC) patients with ILA in the Chinese population. This study aimed to investigate the prevalence, characteristics, oncogenic status and factors associated with overall survival (OS) among NSCLC patients with ILA.
A total of 765 newly diagnosed NSCLC cases at our hospital were reviewed and ILA was diagnosed according to the criteria of the Fleischner Society. The characteristics, clinical pathological features and OS of NSCLC patients with ILA were retrospectively analyzed.
Of the 765 patients included in the study, 101 (13.2%) cases experienced ILA at the time of NSCLC diagnosis. Multivariate analysis revealed that ILA was more likely to be detected in NSCLC patients who were age ≥60 (OR 2.404, p = 0.001), male gender (OR 2.476, p = 0.004), and EGFR wild-type (OR 2.035, p = 0.007). Additionally, according to the multivariate Cox model, the presence of ILA in NSCLC patients was significantly associated with a shorter OS period than those without ILA (751 days vs. 445 days, HR 0.6, p = 0.001). Following analysis, it was determined that OS in patients with usual interstitial pneumonia (UIP) was shorter than in those without UIP (HR 1.82, p = 0.037).
ILA is a common comorbidity among newly diagnosed NSCLC patients. We found that patients with EGFR wild-type NSCLC were more likely to develop ILA. The presence of ILA, especially UIP, was significantly associated with poor NSCLC prognosis.
A total of 765 newly diagnosed NSCLC cases at our hospital were reviewed and ILA was diagnosed according to the criteria of the Fleischner Society. The characteristics, clinical pathological features and OS of NSCLC patients with ILA were retrospectively analyzed.
Of the 765 patients included in the study, 101 (13.2%) cases experienced ILA at the time of NSCLC diagnosis. Multivariate analysis revealed that ILA was more likely to be detected in NSCLC patients who were age ≥60 (OR 2.404, p = 0.001), male gender (OR 2.476, p = 0.004), and EGFR wild-type (OR 2.035, p = 0.007). Additionally, according to the multivariate Cox model, the presence of ILA in NSCLC patients was significantly associated with a shorter OS period than those without ILA (751 days vs. 445 days, HR 0.6, p = 0.001). Following analysis, it was determined that OS in patients with usual interstitial pneumonia (UIP) was shorter than in those without UIP (HR 1.82, p = 0.037).
ILA is a common comorbidity among newly diagnosed NSCLC patients. We found that patients with EGFR wild-type NSCLC were more likely to develop ILA. The presence of ILA, especially UIP, was significantly associated with poor NSCLC prognosis.
摘要：
背景：随着肺癌筛查实施的改进，间质性肺异常（ILA）的识别正在增加。目前,在中国人群中,对新诊断的非小细胞肺癌(NSCLC)ILA患者的致癌状态和ILA亚型的描述有限.本研究旨在调查患病率，特点,ILANSCLC患者的致癌状态和与总生存期（OS）相关的因素。
方法：对我院765例新诊断的NSCLC患者进行回顾性分析，并根据Fleischner协会的标准诊断ILA。的特点,回顾性分析NSCLC合并ILA患者的临床病理特征和OS。
结果：在纳入研究的765名患者中，101例（13.2%）在NSCLC诊断时出现ILA。多因素分析显示，年龄≥60岁的NSCLC患者更容易检测到ILA（OR2.404，p=0.001）。男性（OR2.476，p=0.004），和EGFR野生型（OR2.035，p=0.007）。此外,根据多元Cox模型，与没有ILA的患者相比，NSCLC患者中ILA的存在与较短的OS期显著相关(751天vs.445天,HR0.6，p=0.001)。分析后,经确定,普通间质性肺炎(UIP)患者的OS短于无UIP患者(HR1.82,p=0.037).
结论：ILA是新诊断的NSCLC患者中常见的合并症。我们发现EGFR野生型NSCLC患者更有可能发生ILA。ILA的存在,尤其是UIP，与NSCLC预后不良显著相关。
方法：对我院765例新诊断的NSCLC患者进行回顾性分析，并根据Fleischner协会的标准诊断ILA。的特点,回顾性分析NSCLC合并ILA患者的临床病理特征和OS。
结果：在纳入研究的765名患者中，101例（13.2%）在NSCLC诊断时出现ILA。多因素分析显示，年龄≥60岁的NSCLC患者更容易检测到ILA（OR2.404，p=0.001）。男性（OR2.476，p=0.004），和EGFR野生型（OR2.035，p=0.007）。此外,根据多元Cox模型，与没有ILA的患者相比，NSCLC患者中ILA的存在与较短的OS期显著相关(751天vs.445天,HR0.6，p=0.001)。分析后,经确定,普通间质性肺炎(UIP)患者的OS短于无UIP患者(HR1.82,p=0.037).
结论：ILA是新诊断的NSCLC患者中常见的合并症。我们发现EGFR野生型NSCLC患者更有可能发生ILA。ILA的存在,尤其是UIP，与NSCLC预后不良显著相关。
