METHODS: We analyzed prospectively collected clinical, endoscopic, and histological data from patients enrolled in the Swiss Eosinophilic Esophagitis Cohort Study (SEECS) regarding differences between EoE patients with (EoE/BE+) versus without BE (EoE/BE-) and determined the prevalence of BE in EoE patients.
RESULTS: Among a total of 509 EoE patients included in our analysis, 24 (4.7%) had concomitant BE with a high male preponderance (EoE/BE+ 83.3% vs. EoE/BE- 74.4%). While there were no differences in dysphagia, odynophagia was significantly (12.5 vs. 3.1%, p = 0.047) more common in EoE/BE+ versus EoE/BE-. General well-being at last follow-up was significantly lower in EoE/BE+. Endoscopically, we observed an increased incidence of fixed rings in the proximal esophagus in EoE/BE+ (70.8 vs. 46.3% in EoE/BE-, p = 0.019) and a higher fraction of patients with a severe fibrosis in the proximal histological specimen (8.7 vs. 1.6% in EoE/BE, p = 0.017).
CONCLUSIONS: Our study reveals that BE is twice as frequent in EoE patients compared to general population. Despite many similarities between EoE patients with and without BE, the finding of a more pronounced remodeling in EoE patients with Barrett is noteworthy.
方法:我们分析了前瞻性收集的临床,来自瑞士嗜酸细胞性食管炎队列研究(SEECS)的患者的内镜和组织学数据,关于EoE患者(EoE/BE)与不含BE(EoE/BE-),并确定EoE患者中BE的患病率。
结果:在我们的分析中纳入了509例EoE患者,24例(4.7%)合并有较高的男性优势(EoE/BE83.3%vsEoE/BE-74.4%)。虽然吞咽困难没有差异,食欲不振显着(12.5vs.3.1%,p=0.047)在EoE/BE+与EoE/BE-。EoE/BE+患者末次随访时的总体幸福感明显较低。在内镜下,我们观察到EoE/BE+中近端食管固定环的发生率增加(70.8%vs.46.3%的EoE/BE-,p=0.019),并且在近端组织学标本中严重纤维化的患者比例更高(8.7%vs.1.6%的EoE/BE,p=0.017)。
结论:我们的研究表明,与一般人群相比,EoE患者的BE频率是一般人群的两倍。尽管有和没有Barrett食管的EoE患者之间有许多相似之处,值得注意的是,在使用Barrett的EoE患者中发现更明显的重塑.