Abstract：
This study used contrast-enhanced MRI (CE-MRI) examination to assess the efficacy of high-intensity focused ultrasound (HIFU) for submucosal fibroids.
A total of 81 submucosal fibroids, including 33 cases of type 1, 29 cases of type 2, and 19 cases of type 2-5, treated by HIFU were retrospectively reviewed. CE-MRI was performed in all cases immediately after HIFU, the non-perfused volume ratio (NPVR) and the degree of endometrial impairment were recorded. Thereafter, CE-MRI was repeated in all cases after three months, and the change of fibroid volume shrinkage rate (FVSR), NPVR and the degree of endometrial impairment were recorded.
The immediate NPVR was 86.4 ± 19.3% in type 1, 90.0 ± 13.3% in type 2 and 90.3 ± 7.2% in type 2-5. Among 81 fibroids, grades 0, 1, 2 and 3 endometrial impairments were observed in 38.3%, 16.1%, 14.8% and 30.9%, respectively. Three months later, NPVR was 68.0 ± 36.4% in type 1, 74.3 ± 27.7% in type 2 and 85.0 ± 16.1% in type 2-5. Grades 0, 1, 2 and 3 endometrial impairments were observed in 64.2%, 23.5%, 9.9% and 2.4%.FVSR was 49.0 ± 1.3% in type 1, 39.6 ± 1.7% in type 2 and 37.2 ± 2.1% in type 2-5. The FVSR in submucosal fibroid type 1 was superior to type 2 and type 2-5 (p < 0.05). The NPVR of submucosal fibroids in type 2-5 were higher than type 1 (p < 0.05) .There was no difference among different types of submucosal fibroids in endometrial impairment (p > 0.05) three months after HIFU.
At three months after HIFU, FVSR was better for submucosal fibroid type 1 than for type 2 and type 2-5. And there was no difference in endometrial impairment among the different types of submucosal fibroid groups.
A total of 81 submucosal fibroids, including 33 cases of type 1, 29 cases of type 2, and 19 cases of type 2-5, treated by HIFU were retrospectively reviewed. CE-MRI was performed in all cases immediately after HIFU, the non-perfused volume ratio (NPVR) and the degree of endometrial impairment were recorded. Thereafter, CE-MRI was repeated in all cases after three months, and the change of fibroid volume shrinkage rate (FVSR), NPVR and the degree of endometrial impairment were recorded.
The immediate NPVR was 86.4 ± 19.3% in type 1, 90.0 ± 13.3% in type 2 and 90.3 ± 7.2% in type 2-5. Among 81 fibroids, grades 0, 1, 2 and 3 endometrial impairments were observed in 38.3%, 16.1%, 14.8% and 30.9%, respectively. Three months later, NPVR was 68.0 ± 36.4% in type 1, 74.3 ± 27.7% in type 2 and 85.0 ± 16.1% in type 2-5. Grades 0, 1, 2 and 3 endometrial impairments were observed in 64.2%, 23.5%, 9.9% and 2.4%.FVSR was 49.0 ± 1.3% in type 1, 39.6 ± 1.7% in type 2 and 37.2 ± 2.1% in type 2-5. The FVSR in submucosal fibroid type 1 was superior to type 2 and type 2-5 (p < 0.05). The NPVR of submucosal fibroids in type 2-5 were higher than type 1 (p < 0.05) .There was no difference among different types of submucosal fibroids in endometrial impairment (p > 0.05) three months after HIFU.
At three months after HIFU, FVSR was better for submucosal fibroid type 1 than for type 2 and type 2-5. And there was no difference in endometrial impairment among the different types of submucosal fibroid groups.
摘要：
■本研究使用对比增强MRI（CE-MRI）检查来评估高强度聚焦超声（HIFU）对粘膜下肌瘤的疗效。
■共81个粘膜下肌瘤，回顾性分析HIFU治疗的1型33例，2型29例，2-5型19例。所有病例在HIFU后立即进行CE-MRI，记录非灌注体积比(NPVR)和子宫内膜损伤程度.此后,所有病例在三个月后重复CE-MRI检查,和肌瘤体积收缩率（FVSR）的变化，记录NPVR和子宫内膜损伤程度。
■1型立即NPVR为86.4±19.3％，2型为90.0±13.3％，2-5型为90.3±7.2％。在81个肌瘤中，观察到0、1、2和3级子宫内膜损伤占38.3%，16.1%,14.8%和30.9%，分别。三个月后,1型NPVR为68.0±36.4％，2型为74.3±27.7％，2-5型为85.0±16.1％。在64.2%中观察到0、1、2和3级子宫内膜损伤,23.5%,9.9%和2.4%。1型FVSR为49.0±1.3％，2型为39.6±1.7％，2-5型为37.2±2.1％。1型粘膜下肌瘤的FVSR优于2型和2-5型（p<0.05）。2-5型粘膜下肌瘤的NPVR高于1型（p<0.05）。不同类型粘膜下肌瘤在HIFU术后3个月的子宫内膜损伤方面差异无统计学意义(p>0.05)。
■在HIFU后三个月，1型粘膜下肌瘤的FVSR优于2型和2-5型。不同类型粘膜下肌瘤组的子宫内膜损害无差异。
■共81个粘膜下肌瘤，回顾性分析HIFU治疗的1型33例，2型29例，2-5型19例。所有病例在HIFU后立即进行CE-MRI，记录非灌注体积比(NPVR)和子宫内膜损伤程度.此后,所有病例在三个月后重复CE-MRI检查,和肌瘤体积收缩率（FVSR）的变化，记录NPVR和子宫内膜损伤程度。
■1型立即NPVR为86.4±19.3％，2型为90.0±13.3％，2-5型为90.3±7.2％。在81个肌瘤中，观察到0、1、2和3级子宫内膜损伤占38.3%，16.1%,14.8%和30.9%，分别。三个月后,1型NPVR为68.0±36.4％，2型为74.3±27.7％，2-5型为85.0±16.1％。在64.2%中观察到0、1、2和3级子宫内膜损伤,23.5%,9.9%和2.4%。1型FVSR为49.0±1.3％，2型为39.6±1.7％，2-5型为37.2±2.1％。1型粘膜下肌瘤的FVSR优于2型和2-5型（p<0.05）。2-5型粘膜下肌瘤的NPVR高于1型（p<0.05）。不同类型粘膜下肌瘤在HIFU术后3个月的子宫内膜损伤方面差异无统计学意义(p>0.05)。
■在HIFU后三个月，1型粘膜下肌瘤的FVSR优于2型和2-5型。不同类型粘膜下肌瘤组的子宫内膜损害无差异。
