Abstract：
In nature, arsenic is mostly found in the form of inorganic compounds. Inorganic arsenic compounds have a variety of uses and are currently used in the manufacture of pesticides, preservatives, pharmaceuticals, etc. While inorganic arsenic is widely used, arsenic pollution is increasing worldwide. Public hazards caused by arsenic contamination of drinking water and soil are becoming increasingly evident. Epidemiological and experimental studies have linked inorganic arsenic exposure to the development of many diseases, including cognitive impairment, cardiovascular failure, cancer, etc. Several mechanisms have been proposed to explain the effects caused by arsenic, such as oxidative damage, DNA methylation, and protein misfolding. Understanding the toxicology and potential molecular mechanisms of arsenic can help mitigate its harmful effects. Therefore, this paper reviews the multiple organ toxicity of inorganic arsenic in animals, focusing on the various toxicity mechanisms of arsenic-induced diseases in animals. In addition, we have summarized several drugs that can have therapeutic effects on arsenic poisoning in pursuit of reducing the harm of arsenic contamination from different pathways.
摘要：
在大自然中,砷主要以无机化合物的形式存在。无机砷化合物有多种用途,目前用于制造农药,防腐剂,制药，等。虽然无机砷被广泛使用，砷污染在全球范围内日益增加。饮用水和土壤砷污染造成的公共危害日益明显。流行病学和实验研究已将无机砷暴露与许多疾病的发展联系起来，包括认知障碍，心血管衰竭,癌症,等。已经提出了几种机制来解释砷引起的影响，如氧化损伤，DNA甲基化，和蛋白质错误折叠。了解砷的毒理学和潜在的分子机制可以帮助减轻其有害影响。因此,本文综述了无机砷对动物的多器官毒性,重点研究了砷引起的动物疾病的各种毒性机制。此外,为了从不同途径降低砷污染的危害，我们总结了几种对砷中毒有治疗作用的药物。
