PDF(Pubmed)
Abstract：
The local application of drug-loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties of natural 3D bioactive scaffolds. The scaffolds are functionally modified through chemical and self-assembly approaches with application of polydopamine (PDA) nanoparticles and parathyroid hormone-related peptide-1 (PTHrP-1) for efficient local drug loading. This study investigates the effects of the novel bioactive scaffolds on ossification, osteoclastogenesis, and macrophage polarization. This work elucidates the effects of the scaffolds in regulating osteoclastic activity and new bone formation in vitro. Further studies on the establishment and repair of OP bone defects in small animals are conducted, and the potential of natural bioactive porous scaffold materials to promote the repair of OP bone defects is initially verified. The preparation of safe and economical anti-OP bone repair material provides a theoretical basis for clinical translational applications.
摘要：
载药生物活性支架材料的局部应用是解决临床骨质疏松性骨缺损问题的重要方向之一。这项研究保留了天然3D生物活性支架的载药量和机械性能的优势。通过化学和自组装方法对支架进行功能修饰，并应用聚多巴胺（PDA）纳米颗粒和甲状旁腺激素相关肽-1（PTHrP-1）进行有效的局部载药。这项研究调查了新型生物活性支架对骨化的影响，破骨细胞生成，和巨噬细胞极化。这项工作阐明了支架在体外调节破骨细胞活性和新骨形成中的作用。对小动物OP骨缺损的建立和修复进行了进一步的研究，并初步验证了天然生物活性多孔支架材料促进OP骨缺损修复的潜力。制备安全、经济的抗OP骨修复材料为临床转化应用提供了理论依据。
