PDF(Pubmed)
Abstract：
UNASSIGNED: Myofasciitis is a heterogeneous group of diseases pathologically characterized by inflammatory cell infiltration into the fascia. Endothelial activation plays a critical role in the pathogenesis of the inflammatory response. However, the expression of cellular adhesion molecules (CAMs) in myofasciitis has not been investigated.
UNASSIGNED: Data on clinical features, thigh magnetic resonance imaging, and muscle pathology were collected from five patients with myofasciitis. Immunohistochemical (IHC) staining and Western blot (WB) of the muscle biopsies from patients and healthy controls were performed.
UNASSIGNED: Increased levels of serum pro-inflammatory cytokines, including IL-6, TNF-α, and IL-2R, were detected in four patients. IHC staining and WB indicated significantly increased expression of cell adhesion molecules in blood vessels or inflammatory cells within the perimysium in muscle and fascia tissues of patients with myofasciitis compared to controls.
UNASSIGNED: The up-regulation of CAMs in myofasciitis indicates endothelial activation, which may be potential therapy targets for the treatment of myofasciitis.
UNASSIGNED: Data on clinical features, thigh magnetic resonance imaging, and muscle pathology were collected from five patients with myofasciitis. Immunohistochemical (IHC) staining and Western blot (WB) of the muscle biopsies from patients and healthy controls were performed.
UNASSIGNED: Increased levels of serum pro-inflammatory cytokines, including IL-6, TNF-α, and IL-2R, were detected in four patients. IHC staining and WB indicated significantly increased expression of cell adhesion molecules in blood vessels or inflammatory cells within the perimysium in muscle and fascia tissues of patients with myofasciitis compared to controls.
UNASSIGNED: The up-regulation of CAMs in myofasciitis indicates endothelial activation, which may be potential therapy targets for the treatment of myofasciitis.
摘要：
■肌筋膜炎是一组异质性疾病，其病理特征是炎性细胞浸润到筋膜中。内皮激活在炎症反应的发病机理中起着至关重要的作用。然而,尚未研究肌筋膜炎中细胞粘附分子（CAM）的表达。
■临床特征数据，大腿磁共振成像,收集了5例肌筋膜炎患者的肌肉病理。对患者和健康对照的肌肉活检进行免疫组织化学(IHC)染色和蛋白质印迹(WB)。
■血清促炎细胞因子水平升高，包括IL-6，TNF-α，和IL-2R,在四名患者中检测到。IHC染色和WB表明，与对照组相比，肌筋膜炎患者的肌肉和筋膜组织中血管或周围炎症细胞中细胞粘附分子的表达显着增加。
■肌筋膜炎中CAM的上调表明内皮激活，这可能是治疗肌筋膜炎的潜在治疗目标。
■临床特征数据，大腿磁共振成像,收集了5例肌筋膜炎患者的肌肉病理。对患者和健康对照的肌肉活检进行免疫组织化学(IHC)染色和蛋白质印迹(WB)。
■血清促炎细胞因子水平升高，包括IL-6，TNF-α，和IL-2R,在四名患者中检测到。IHC染色和WB表明，与对照组相比，肌筋膜炎患者的肌肉和筋膜组织中血管或周围炎症细胞中细胞粘附分子的表达显着增加。
■肌筋膜炎中CAM的上调表明内皮激活，这可能是治疗肌筋膜炎的潜在治疗目标。
