PDF(Pubmed)
Abstract：
This study examined the effects of human immunodeficiency virus (HIV) on resting state functional connectivity (RSFC) in a large cohort of people with HIV (PWH) and healthy controls without HIV (PWoH). Within PWH analyses focused on the effects of viral suppression and cognitive impairment on RSFC.
A total of 316 PWH on stable combination antiretroviral therapy and 209 demographically matched PWoH were scanned at a single institution. Effects of the virus were examined by grouping PWH by detectable (viral load > 20 copies/mL; VLD) and undetectable (VLU) viral loads and as being cognitively impaired (CI) (Global Deficit Score ≥ 0.5) or cognitively normal (CN). Regression analysis, object oriented data analysis, and spring embedded graph models were applied to RSFC measures from 298 established brain regions of interest comprising 13 brain networks to examine group differences.
No significant RSFC differences were observed between PWH and PWoH. Within PWH, there were no significant differences in RSFC between VLD and VLU subgroups and CI and CN subgroups.
There were no significant effects of HIV on RSFC in our relatively large cohort of PWH and PWoH. Future studies could increase the sample size and combine with other imaging modalities.
A total of 316 PWH on stable combination antiretroviral therapy and 209 demographically matched PWoH were scanned at a single institution. Effects of the virus were examined by grouping PWH by detectable (viral load > 20 copies/mL; VLD) and undetectable (VLU) viral loads and as being cognitively impaired (CI) (Global Deficit Score ≥ 0.5) or cognitively normal (CN). Regression analysis, object oriented data analysis, and spring embedded graph models were applied to RSFC measures from 298 established brain regions of interest comprising 13 brain networks to examine group differences.
No significant RSFC differences were observed between PWH and PWoH. Within PWH, there were no significant differences in RSFC between VLD and VLU subgroups and CI and CN subgroups.
There were no significant effects of HIV on RSFC in our relatively large cohort of PWH and PWoH. Future studies could increase the sample size and combine with other imaging modalities.
摘要：
背景：这项研究检查了人类免疫缺陷病毒（HIV）对HIV感染者（PWH）和无HIV健康对照者（PWoH）的静息状态功能连接（RSFC）的影响。在PWH中，分析的重点是病毒抑制和认知障碍对RSFC的影响。
方法：在一个机构共扫描了316例稳定联合抗逆转录病毒疗法的PWH和209例人口统计学上匹配的PWoH。通过按可检测（病毒载量>20拷贝/mL;VLD）和不可检测（VLU）病毒载量以及认知受损（CI）（全球缺陷评分≥0.5）或认知正常（CN）对PWH进行分组来检查病毒的影响。回归分析,面向对象的数据分析，和弹簧嵌入图模型被应用于包含13个大脑网络的298个已建立的大脑感兴趣区域的RSFC测量，以检查组差异。
结果：在PWH和PWoH之间没有观察到显著的RSFC差异。在PWH内,VLD和VLU亚组与CI和CN亚组之间的RSFC没有显着差异。
结论：在我们相对较大的PWH和PWoH队列中，HIV对RSFC没有显著影响。未来的研究可以增加样本量，并与其他成像方式相结合。
方法：在一个机构共扫描了316例稳定联合抗逆转录病毒疗法的PWH和209例人口统计学上匹配的PWoH。通过按可检测（病毒载量>20拷贝/mL;VLD）和不可检测（VLU）病毒载量以及认知受损（CI）（全球缺陷评分≥0.5）或认知正常（CN）对PWH进行分组来检查病毒的影响。回归分析,面向对象的数据分析，和弹簧嵌入图模型被应用于包含13个大脑网络的298个已建立的大脑感兴趣区域的RSFC测量，以检查组差异。
结果：在PWH和PWoH之间没有观察到显著的RSFC差异。在PWH内,VLD和VLU亚组与CI和CN亚组之间的RSFC没有显着差异。
结论：在我们相对较大的PWH和PWoH队列中，HIV对RSFC没有显著影响。未来的研究可以增加样本量，并与其他成像方式相结合。
