Abstract：
Diabetic foot ulcer (DFU) is globally a major health burden predisposing to limb amputation. Among the various treatment modalities, platelet-rich plasma (PRP) is emerging as a promising agent. It stimulates wound healing by providing a higher concentration of essential growth factors locally. Though the role of PRP in DFU healing is established, still the route of administration with maximal efficacy is yet to be defined. Our study aims to evaluate the efficacy of autologous PRP in the treatment of diabetic ulcers and compare the effect of topical and perilesional injections of PRP in DFU healing. We conducted a single-centre, prospective, interventional study on 60 patients with DFU, in 2 groups of 30 patients each. They were treated with freshly prepared autologous PRP injection perilesionally and topically respectively, once a week for 4 weeks. Ulcer size was assessed, using \"imito-measure\" software at presentation and 2, 4, 8, and 12 weeks post-therapy. Serum MMP-9 levels were assessed in both groups, pretreatment and post-treatment. For statistical analysis, SPSS software V-23 was used. On assessment, both groups had comparable baseline characteristics, Wagner\'s grading, and glycemic indices. The percentage reduction in the size of the wound at 2 weeks, 1 month, 2 months, and 3 months was greater in the perilesional group as compared to the topical PRP group.
摘要：
糖尿病足溃疡（DFU）是全球范围内易导致截肢的主要健康负担。在各种治疗方式中，富血小板血浆（PRP）正在成为一种有前途的药物。它通过局部提供较高浓度的必需生长因子来刺激伤口愈合。虽然PRP在DFU愈合中的作用已经确立，然而，具有最大疗效的给药途径尚未确定。我们的研究旨在评估自体PRP治疗糖尿病溃疡的疗效，并比较局部和病灶周围注射PRP在DFU愈合中的作用。我们进行了一个单中心，prospective,60例DFU患者的介入研究，两组各30例。他们分别在围手术期和局部用新鲜制备的自体PRP注射治疗，每周一次，共4周。评估溃疡大小，在演示和治疗后2、4、8和12周使用“imito-measure”软件。评估两组患者血清MMP-9水平,预处理和后处理。为了进行统计分析，采用SPSS软件V-23。关于评估，两组均有相当的基线特征,瓦格纳的评分,和血糖指数。2周时伤口大小减少的百分比，1个月,2个月,与局部PRP组相比，病灶周围组的3个月时间更长。
