PDF(Pubmed)
Abstract：
The human brain contributes 2% of the body weight yet receives 15% of cardiac output and demands a constant supply of oxygen (O 2) and nutrients to meet its metabolic needs. Cerebral autoregulation is responsible for maintaining a constant cerebral blood flow that provides the supply of oxygen and maintains the energy storage capacity. We selected oxygen administration-related studies published between 1975-2021 that included meta-analysis, original research, commentaries, editorial, and review articles. In the present narrative review, several important aspects of the oxygen effects on brain tissues and cerebral autoregulation are discussed, as well the role of exogenous O 2 administration in patients with chronic ischemic cerebrovascular disease: We aimed to revisit the utility of O 2 administration in pathophysiological situations whether or not being advantageous. Indeed, a compelling clinical and experimental body of evidence questions the utility of routine oxygen administration in acute and post-recovery brain ischemia, as evident by studies in neurophysiology imaging. While O 2 is still part of common clinical practice, it remains unclear whether its routine use is safe.
摘要：
人的大脑贡献了2％的体重，但却接收了15％的心输出量，并需要恒定的氧气（O2）和营养物质来满足其代谢需求。脑自动调节负责维持恒定的脑血流量，提供氧气供应并维持能量储存能力。我们选择了1975-2021年间发表的氧气管理相关研究，包括荟萃分析，原创研究,评论,社论,并审查文章。在当前的叙述回顾中，讨论了氧气对脑组织和大脑自动调节的几个重要方面，以及外源性O2给药在慢性缺血性脑血管病患者中的作用：我们旨在重新审视O2给药在病理生理情况下的效用，无论是否有利。的确,一个令人信服的临床和实验证据质疑常规氧气在急性和恢复后脑缺血中的实用性，神经生理学成像研究证明了这一点。虽然O2仍然是常见临床实践的一部分，目前尚不清楚其常规使用是否安全。
