Abstract：
Comparative analysis of the genomic sequences of multiple hepatitis E virus (HEV) isolates has revealed extensive genomic diversity among them. Recently, a variety of genetically distinct HEV variants have also been isolated and identified from large numbers of animal species, including birds, rabbits, rats, ferrets, bats, cutthroat trout, and camels, among others. Furthermore, it has been reported that recombination in HEV genomes takes place in animals and in human patients. Also, chronic HEV infection in immunocompromised individuals has revealed the presence of viral strains carrying insertions from human genes. This paper reviews current knowledge on the genomic variability and evolution of HEV.
摘要：
对多种戊型肝炎病毒（HEV）分离株的基因组序列的比较分析揭示了它们之间广泛的基因组多样性。最近,还从大量动物物种中分离并鉴定了多种遗传上不同的HEV变体，包括鸟类,兔子,老鼠,雪貂,蝙蝠,割喉鳟鱼,还有骆驼,在其他人中。此外，据报道,HEV基因组中的重组发生在动物和人类患者中。此外，免疫功能低下个体的慢性HEV感染揭示了携带人类基因插入的病毒株的存在。本文综述了HEV基因组变异性和进化的最新知识。
