PDF(Pubmed)
Abstract：
Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving both upper and lower motor neurons. Interestingly, 15 to 41% of patients with ALS have concomitant frontotemporal dementia (FTD). Approximately, 50% of patients with ALS can copresent with a broader set of neuropsychological pathologies that do not meet FTD diagnostic criteria. This association resulted in revised and expanded criteria establishing the ALS-frontotemporal spectrum disorder (FTSD). In this case report, we review background information, epidemiology, pathophysiology, and structural and molecular imaging features of ALS-FTSD.
摘要：
肌萎缩侧索硬化症（ALS）是一种致命的进行性神经退行性疾病，涉及上运动神经元和下运动神经元。有趣的是,15％至41％的ALS患者伴有额颞叶痴呆（FTD）。大约,50％的ALS患者可以与不符合FTD诊断标准的更广泛的神经心理疾病共存。这种关联导致修订和扩展了建立ALS-额颞叶谱系障碍（FTSD）的标准。在这个案例报告中,我们回顾背景资料,流行病学,病理生理学,ALS-FTSD的结构和分子影像学特征。
