Abstract：
To explore the effects of silver diamine fluoride (SDF) on the microbial community of carious lesions.
Original studies evaluating the effect of SDF treatment on the microbial community of human carious lesions were included.
A systematic search of English-language publications was performed in PubMed, EMBASE, Scopus, and Web of Science. Gray literature was searched in ClinicalTrials.gov and Google Scholar.
This review included seven publications reporting the effects of SDF on microbial community of dental plaque or carious dentin, including the microbial biodiversity, relative abundance of microbial taxa, and predicted functional pathways of the microbial community. The studies on microbial community of dental plaque reported that SDF did not have a significant effect on both the within-community species diversity (alpha-diversity) and inter-community microbial compositional dissimilarity (beta-diversity) of the plaque microbial communities. However, SDF changed the relative abundance of 29 bacterial species of plaque community, inhibited carbohydrate transportation and interfered with the metabolic functions of the plaque microbial community. A study on the microbial community in dentin carious lesions reported that SDF affected its beta-diversity and changed the relative abundance of 14 bacterial species.
SDF showed no significant effects on the biodiversity of the plaque microbial community but changed the beta-diversity of the carious dentin microbial community. SDF could change the relative abundance of certain bacterial species in the dental plaque and the carious dentin. SDF could also affect the predicted functional pathways of the microbial community.
This review provided comprehensive evidence on the potential effect of SDF treatment on the microbial community of carious lesions.
Original studies evaluating the effect of SDF treatment on the microbial community of human carious lesions were included.
A systematic search of English-language publications was performed in PubMed, EMBASE, Scopus, and Web of Science. Gray literature was searched in ClinicalTrials.gov and Google Scholar.
This review included seven publications reporting the effects of SDF on microbial community of dental plaque or carious dentin, including the microbial biodiversity, relative abundance of microbial taxa, and predicted functional pathways of the microbial community. The studies on microbial community of dental plaque reported that SDF did not have a significant effect on both the within-community species diversity (alpha-diversity) and inter-community microbial compositional dissimilarity (beta-diversity) of the plaque microbial communities. However, SDF changed the relative abundance of 29 bacterial species of plaque community, inhibited carbohydrate transportation and interfered with the metabolic functions of the plaque microbial community. A study on the microbial community in dentin carious lesions reported that SDF affected its beta-diversity and changed the relative abundance of 14 bacterial species.
SDF showed no significant effects on the biodiversity of the plaque microbial community but changed the beta-diversity of the carious dentin microbial community. SDF could change the relative abundance of certain bacterial species in the dental plaque and the carious dentin. SDF could also affect the predicted functional pathways of the microbial community.
This review provided comprehensive evidence on the potential effect of SDF treatment on the microbial community of carious lesions.
摘要：
目的：探讨二氟化银(SDF)对龋损微生物群落的影响。
方法：纳入了评估SDF治疗对人龋病变微生物群落影响的原始研究。
方法：在PubMed，EMBASE,Scopus,和WebofScience。在ClinicalTrials.gov和GoogleScholar中搜索了灰色文献。
结果：这篇综述包括七篇出版物，报道了SDF对牙菌斑或龋齿牙本质微生物群落的影响，包括微生物的生物多样性,微生物类群的相对丰度，并预测了微生物群落的功能途径。对牙菌斑微生物群落的研究报告说，SDF对牙菌斑微生物群落的群落内物种多样性（α-多样性）和群落间微生物组成差异（β-多样性）没有显着影响。然而,SDF改变了29种菌斑群落细菌的相对丰度，抑制碳水化合物的运输并干扰斑块微生物群落的代谢功能。对牙本质龋病变中微生物群落的研究报告说，SDF影响了其β-多样性并改变了14种细菌的相对丰度。
结论：SDF对牙菌斑微生物群落的生物多样性没有显著影响，但改变了龋齿牙本质微生物群落的β-多样性。SDF可以改变牙菌斑和龋齿牙本质中某些细菌种类的相对丰度。SDF还可以影响微生物群落的预测功能途径。
结论：这篇综述提供了关于SDF治疗对龋齿病变微生物群落潜在影响的综合证据。
方法：纳入了评估SDF治疗对人龋病变微生物群落影响的原始研究。
方法：在PubMed，EMBASE,Scopus,和WebofScience。在ClinicalTrials.gov和GoogleScholar中搜索了灰色文献。
结果：这篇综述包括七篇出版物，报道了SDF对牙菌斑或龋齿牙本质微生物群落的影响，包括微生物的生物多样性,微生物类群的相对丰度，并预测了微生物群落的功能途径。对牙菌斑微生物群落的研究报告说，SDF对牙菌斑微生物群落的群落内物种多样性（α-多样性）和群落间微生物组成差异（β-多样性）没有显着影响。然而,SDF改变了29种菌斑群落细菌的相对丰度，抑制碳水化合物的运输并干扰斑块微生物群落的代谢功能。对牙本质龋病变中微生物群落的研究报告说，SDF影响了其β-多样性并改变了14种细菌的相对丰度。
结论：SDF对牙菌斑微生物群落的生物多样性没有显著影响，但改变了龋齿牙本质微生物群落的β-多样性。SDF可以改变牙菌斑和龋齿牙本质中某些细菌种类的相对丰度。SDF还可以影响微生物群落的预测功能途径。
结论：这篇综述提供了关于SDF治疗对龋齿病变微生物群落潜在影响的综合证据。
