Abstract：
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare autoimmune inflammatory disease characterized by osteoarticular and dermatological manifestations. The most common osteoarticular manifestations involve the anterior chest wall, axial skeleton, and long bones. Cranial bone involvement is less reported in SAPHO syndrome. We herein present three cases of SAPHO syndrome with cranial bone involvement, and review the previous literature on similar manifestations. It was revealed that SAPHO syndrome could lead to cranial bone involvement, which could involve the dura mater, leading to hypertrophic pachymeningitis, but the outcome is usually good. Janus kinase inhibitors may be a potential treatment option.
摘要：
滑膜炎,痤疮,脓疱病,骨增生,骨炎（SAPHO）综合征是一种罕见的自身免疫性炎症性疾病，以骨关节和皮肤病表现为特征。最常见的骨关节表现涉及前胸壁，轴向骨架,和长骨。在SAPHO综合征中，颅骨受累的报道较少。我们在此介绍三例SAPHO综合征伴颅骨受累，并回顾了以前关于类似表现的文献。据透露，SAPHO综合征可能导致颅骨受累，可能涉及硬脑膜，导致肥厚性硬脑膜炎,但结果通常是好的。Janus激酶抑制剂可能是一种潜在的治疗选择。
