PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to investigate the microscopic structure and characteristics of nevi on the conjunctiva of the lacrimal caruncle by in vivo confocal microscopy.
UNASSIGNED: In total, four patients with nevi growing on the lacrimal caruncle conjunctiva were recruited. The morphological characteristics of the nevi were evaluated by in vivo confocal microscopy before excision surgery; the results were compared with histopathological analyses of the surgical specimens.
UNASSIGNED: The nevi of the four patients were all located at the conjunctiva of the lacrimal caruncle, with a slightly nodular surface, mixed black and brown color, and clear boundary. The nevi were round and highly protruded on the surface of the lacrimal caruncle, with an average diameter of 4.5 ± 1.29 mm. Under in vivo confocal microscopy, the pigmented nevus cells on the conjunctiva of the lacrimal caruncle were observed to be clustered in nests with irregular boundaries. The cells were round or irregular, with clear cell boundaries, hyper-reflective at the periphery, with low reflectivity in the center. Vascular crawling was observed in some regions. Histopathological analysis showed that nevus cells were roughly equal in size and distributed in a nodular pattern. Melanin granules were observed in the cytoplasm. No atypia or mitotic figures of the cells were found.
UNASSIGNED: This study revealed that the microstructure of nevi growing on the conjunctiva of the lacrimal caruncle can be identified by in vivo confocal microscopy.
UNASSIGNED: In total, four patients with nevi growing on the lacrimal caruncle conjunctiva were recruited. The morphological characteristics of the nevi were evaluated by in vivo confocal microscopy before excision surgery; the results were compared with histopathological analyses of the surgical specimens.
UNASSIGNED: The nevi of the four patients were all located at the conjunctiva of the lacrimal caruncle, with a slightly nodular surface, mixed black and brown color, and clear boundary. The nevi were round and highly protruded on the surface of the lacrimal caruncle, with an average diameter of 4.5 ± 1.29 mm. Under in vivo confocal microscopy, the pigmented nevus cells on the conjunctiva of the lacrimal caruncle were observed to be clustered in nests with irregular boundaries. The cells were round or irregular, with clear cell boundaries, hyper-reflective at the periphery, with low reflectivity in the center. Vascular crawling was observed in some regions. Histopathological analysis showed that nevus cells were roughly equal in size and distributed in a nodular pattern. Melanin granules were observed in the cytoplasm. No atypia or mitotic figures of the cells were found.
UNASSIGNED: This study revealed that the microstructure of nevi growing on the conjunctiva of the lacrimal caruncle can be identified by in vivo confocal microscopy.
摘要：
■本研究旨在通过体内共聚焦显微镜研究泪栓结膜上痣的微观结构和特征。
■总共，招募了四名在泪滴结膜上生长痣的患者。切除手术前通过体内共聚焦显微镜评估痣的形态特征；将结果与手术标本的组织病理学分析进行比较。
■4名患者的痣均位于泪滴结膜，表面有轻微的结节，混合黑色和棕色，清晰的边界。痣呈圆形，高度突出在泪滴表面，平均直径4.5±1.29mm。在体内共聚焦显微镜下，观察到泪栓结膜上的色素痣细胞聚集在具有不规则边界的巢中。细胞是圆形或不规则的，细胞边界清晰,在外围过度反射，低反射率的中心。在某些地区观察到血管爬行。组织病理学分析显示痣细胞大小大致相等，呈结节状分布。在细胞质中观察到黑色素颗粒。未发现细胞的异型性或有丝分裂图。
■这项研究表明，可以通过体内共聚焦显微镜来鉴定在泪滴结膜上生长的痣的微观结构。
■总共，招募了四名在泪滴结膜上生长痣的患者。切除手术前通过体内共聚焦显微镜评估痣的形态特征；将结果与手术标本的组织病理学分析进行比较。
■4名患者的痣均位于泪滴结膜，表面有轻微的结节，混合黑色和棕色，清晰的边界。痣呈圆形，高度突出在泪滴表面，平均直径4.5±1.29mm。在体内共聚焦显微镜下，观察到泪栓结膜上的色素痣细胞聚集在具有不规则边界的巢中。细胞是圆形或不规则的，细胞边界清晰,在外围过度反射，低反射率的中心。在某些地区观察到血管爬行。组织病理学分析显示痣细胞大小大致相等，呈结节状分布。在细胞质中观察到黑色素颗粒。未发现细胞的异型性或有丝分裂图。
■这项研究表明，可以通过体内共聚焦显微镜来鉴定在泪滴结膜上生长的痣的微观结构。
