PDF(Pubmed)
Abstract：
UNASSIGNED: Neurofilament light chain protein (NfL) is a fluid biomarker of neural injury measurable in cerebrospinal fluid and blood. Patients with different neurodegenerative disorders and mild traumatic brain injury display elevated levels of NfL. However, so far, elevated levels of NfL have not been demonstrated in persons with psychiatric disorders. To our knowledge, the occurrence of NfL in the blood has not previously been studied in persons undergoing forensic psychiatric assessment or persons treated in forensic mental health services. Supposedly, these persons suffer from experiences and conditions with a higher risk of neural injury than other psychiatric patients.
UNASSIGNED: In this pilot study, we investigated plasma levels of NfL in 20 persons undergoing forensic psychiatric assessment and 20 patients at a forensic psychiatric hospital. NfL values were compared with control groups of healthy individuals matched for age and sex.
UNASSIGNED: The prevalence of increased NfL in both forensic groups was low and did not differ compared with the controls. However, some persons undergoing forensic psychiatric assessment showed slightly elevated values.
UNASSIGNED: The slightly elevated values were observed in the group investigated closer in time to the index crime, when elevated NfL levels could be expected to be more prevalent due to acute conditions from the time of the offense. This gives reason to look further into this group.
UNASSIGNED: In this pilot study, we investigated plasma levels of NfL in 20 persons undergoing forensic psychiatric assessment and 20 patients at a forensic psychiatric hospital. NfL values were compared with control groups of healthy individuals matched for age and sex.
UNASSIGNED: The prevalence of increased NfL in both forensic groups was low and did not differ compared with the controls. However, some persons undergoing forensic psychiatric assessment showed slightly elevated values.
UNASSIGNED: The slightly elevated values were observed in the group investigated closer in time to the index crime, when elevated NfL levels could be expected to be more prevalent due to acute conditions from the time of the offense. This gives reason to look further into this group.
摘要：
■神经丝轻链蛋白（NfL）是在脑脊液和血液中可测量的神经损伤的流体生物标志物。患有不同神经退行性疾病和轻度创伤性脑损伤的患者显示NfL水平升高。然而,到目前为止,在患有精神疾病的患者中尚未发现NfL水平升高。据我们所知,以前尚未在接受法医精神病学评估的人或在法医精神卫生服务机构接受治疗的人中研究血液中NfL的发生。据说，与其他精神病患者相比，这些患者的神经损伤风险更高。
■在这项试点研究中，我们调查了20名接受法医精神病评估的患者和20名法医精神病医院患者的血浆NfL水平.将NfL值与年龄和性别相匹配的健康个体的对照组进行比较。
■两个法医组中NfL升高的患病率较低，与对照组相比没有差异。然而,一些接受法医精神病学评估的人的价值略有升高。
■在更接近指数犯罪的调查组中观察到略微升高的值，当NfL水平升高可能会更普遍，由于从进攻时的急性条件。这就有理由进一步研究这个群体。
■在这项试点研究中，我们调查了20名接受法医精神病评估的患者和20名法医精神病医院患者的血浆NfL水平.将NfL值与年龄和性别相匹配的健康个体的对照组进行比较。
■两个法医组中NfL升高的患病率较低，与对照组相比没有差异。然而,一些接受法医精神病学评估的人的价值略有升高。
■在更接近指数犯罪的调查组中观察到略微升高的值，当NfL水平升高可能会更普遍，由于从进攻时的急性条件。这就有理由进一步研究这个群体。
