PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the involvement of retinal traction in the pathogenesis of lamellar macular hole (LMH) and related diseases based on OCT-based consensus definition.
UNASSIGNED: Retrospective, observational study.
UNASSIGNED: Seventy-two eyes with LMH, epiretinal membrane foveoschisis (ERM-FS), or macular pseudohole (MPH).
UNASSIGNED: To quantitatively evaluate the involvement and strength of retinal traction in their pathogenesis, retinal folds were visualized with en face OCT imaging, and the maximum depth of the parafoveal retinal folds (MDRF) was measured. Metamorphopsia was quantified by measuring the minimum visual angle of dotted lines needed to cause it to disappear using M-CHARTS (Inami).
UNASSIGNED: Maximum depth of retinal folds and M-CHARTS scores.
UNASSIGNED: Of the 72 eyes, 26 were classified as having LMH, 25 as having ERM-FS, and 21 as having MPH. Parafoveal retinal folds were observed in 7 (26.9%) eyes with LMH, 25 (100%) with ERM-FS, and 21 (100%) with MPH. The MDRF (7.5 ± 17.6 μm) was significantly smaller in LMH than in ERM-FS (86.3 ± 31.4 μm) and MPH (74.5 ± 24.6 μm) (both P < 0.001), whereas no significant difference in MDRF between MPH and ERM-FS was observed (P = 0.43). A significant positive correlation between MDRF and M-CHARTS scores was observed in ERM-FS and MPH (P = 0.008 and 0.040, respectively) but not in LMH (P = 0.073).
UNASSIGNED: Retinal traction was significantly weaker in the LMH group than in the ERM-FS and MPH groups. The MDRF was significantly associated with the degree of metamorphopsia in the ERM-FS and MPH groups. These results provide insights into the diseases\' pathophysiology and treatment strategy.
UNASSIGNED: Retrospective, observational study.
UNASSIGNED: Seventy-two eyes with LMH, epiretinal membrane foveoschisis (ERM-FS), or macular pseudohole (MPH).
UNASSIGNED: To quantitatively evaluate the involvement and strength of retinal traction in their pathogenesis, retinal folds were visualized with en face OCT imaging, and the maximum depth of the parafoveal retinal folds (MDRF) was measured. Metamorphopsia was quantified by measuring the minimum visual angle of dotted lines needed to cause it to disappear using M-CHARTS (Inami).
UNASSIGNED: Maximum depth of retinal folds and M-CHARTS scores.
UNASSIGNED: Of the 72 eyes, 26 were classified as having LMH, 25 as having ERM-FS, and 21 as having MPH. Parafoveal retinal folds were observed in 7 (26.9%) eyes with LMH, 25 (100%) with ERM-FS, and 21 (100%) with MPH. The MDRF (7.5 ± 17.6 μm) was significantly smaller in LMH than in ERM-FS (86.3 ± 31.4 μm) and MPH (74.5 ± 24.6 μm) (both P < 0.001), whereas no significant difference in MDRF between MPH and ERM-FS was observed (P = 0.43). A significant positive correlation between MDRF and M-CHARTS scores was observed in ERM-FS and MPH (P = 0.008 and 0.040, respectively) but not in LMH (P = 0.073).
UNASSIGNED: Retinal traction was significantly weaker in the LMH group than in the ERM-FS and MPH groups. The MDRF was significantly associated with the degree of metamorphopsia in the ERM-FS and MPH groups. These results provide insights into the diseases\' pathophysiology and treatment strategy.
摘要：
■根据基于OCT的共识定义，研究视网膜牵引在板层黄斑裂孔（LMH）和相关疾病的发病机制中的作用。
■回顾性，观察性研究。
■72只眼睛与LMH，视网膜前膜中央凹（ERM-FS），或黄斑假孔（MPH）。
■为了定量评估视网膜牵引在其发病机理中的受累和强度，视网膜皱褶通过面部OCT成像可视化，并测量了旁凹视网膜褶皱（MDRF）的最大深度。通过使用M-CHARTS（Inami）测量使其消失所需的虚线的最小视角来量化变形。
■最大视网膜褶皱深度和M-CHARTS评分。
■在72只眼睛中,26人被归类为患有LMH，25为具有ERM-FS，21为MPH。在LMH的7只（26.9％）眼中观察到了下凹视网膜褶皱，25（100%）与ERM-FS，和21（100%）与MPH。LMH的MDRF（7.5±17.6μm）明显小于ERM-FS（86.3±31.4μm）和MPH（74.5±24.6μm）（均P<0.001），而MPH和ERM-FS之间的MDRF没有显着差异（P=0.43）。在ERM-FS和MPH中观察到MDRF和M-CHARTS评分之间的显着正相关（分别为P=0.008和0.040），而在LMH中没有（P=0.073）。
■LMH组的视网膜牵引明显弱于ERM-FS和MPH组。在ERM-FS和MPH组中，MDRF与变形程度显着相关。这些结果为疾病的病理生理学和治疗策略提供了见解。
■回顾性，观察性研究。
■72只眼睛与LMH，视网膜前膜中央凹（ERM-FS），或黄斑假孔（MPH）。
■为了定量评估视网膜牵引在其发病机理中的受累和强度，视网膜皱褶通过面部OCT成像可视化，并测量了旁凹视网膜褶皱（MDRF）的最大深度。通过使用M-CHARTS（Inami）测量使其消失所需的虚线的最小视角来量化变形。
■最大视网膜褶皱深度和M-CHARTS评分。
■在72只眼睛中,26人被归类为患有LMH，25为具有ERM-FS，21为MPH。在LMH的7只（26.9％）眼中观察到了下凹视网膜褶皱，25（100%）与ERM-FS，和21（100%）与MPH。LMH的MDRF（7.5±17.6μm）明显小于ERM-FS（86.3±31.4μm）和MPH（74.5±24.6μm）（均P<0.001），而MPH和ERM-FS之间的MDRF没有显着差异（P=0.43）。在ERM-FS和MPH中观察到MDRF和M-CHARTS评分之间的显着正相关（分别为P=0.008和0.040），而在LMH中没有（P=0.073）。
■LMH组的视网膜牵引明显弱于ERM-FS和MPH组。在ERM-FS和MPH组中，MDRF与变形程度显着相关。这些结果为疾病的病理生理学和治疗策略提供了见解。
