PDF(Pubmed)
Abstract：
UNASSIGNED: It is unknown whether there is an association between 25-hydroxyvitamin D (25(OH)D) level and thyroid disease in postmenopausal women with type 2 diabetes. This study aimed to evaluate the relationship between blood 25(OH)D levels and thyroid function in postmenopausal women with type 2 diabetes mellitus (T2DM).
UNASSIGNED: This cross-sectional study involved Chinese postmenopausal women who presented to our diabetes clinic from March 2021 to May 2022 and were diagnosed with T2DM collected via a convenience sampling method. Blood samples were obtained from each patient to detect serum thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and 25(OH)D levels. Deficiency was defined as a 25(OH)D < 20 ng/mL. Comparative analysis was via t-test or chi-square test. Pearson correlation was then used to estimate the relationship between different thyroid function parameters and 25(OH)D. Multivariate logistic regression analysis was used to explore potential risk factors for 25(OH)D deficiency.
UNASSIGNED: In total, 157 out of 230 participants (68.26%) had 25(OH)D deficiency. Compared with patients with normal 25(OH)D levels, patients with 25(OH)D deficiency had shorter medical histories of diabetes mellitus (DM, p = 0.001) and higher rates of hyperthyroidism (p = 0.007), hypothyroidism (p < 0.001), TPOAb positive (p < 0.001) and TgAb positive (p < 0.001). Correlation analysis revealed that TSH (r = -0.144, p = 0.030), FT4 (r = -0.145, p = 0.029), TPOAb (r = -0.216, p = 0.001) and TgAb (r = -0.150, p = 0.024) levels were correlated with serum 25(OH)D levels. Further multivariable logistic regression analyses suggested that the length of DM history, presence of hyperthyroidism, presence of hypothyroidism and positive TPOAb were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM.
UNASSIGNED: Hyperthyroidism, hypothyroidism and TPOAb positivity were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM.
UNASSIGNED: This cross-sectional study involved Chinese postmenopausal women who presented to our diabetes clinic from March 2021 to May 2022 and were diagnosed with T2DM collected via a convenience sampling method. Blood samples were obtained from each patient to detect serum thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and 25(OH)D levels. Deficiency was defined as a 25(OH)D < 20 ng/mL. Comparative analysis was via t-test or chi-square test. Pearson correlation was then used to estimate the relationship between different thyroid function parameters and 25(OH)D. Multivariate logistic regression analysis was used to explore potential risk factors for 25(OH)D deficiency.
UNASSIGNED: In total, 157 out of 230 participants (68.26%) had 25(OH)D deficiency. Compared with patients with normal 25(OH)D levels, patients with 25(OH)D deficiency had shorter medical histories of diabetes mellitus (DM, p = 0.001) and higher rates of hyperthyroidism (p = 0.007), hypothyroidism (p < 0.001), TPOAb positive (p < 0.001) and TgAb positive (p < 0.001). Correlation analysis revealed that TSH (r = -0.144, p = 0.030), FT4 (r = -0.145, p = 0.029), TPOAb (r = -0.216, p = 0.001) and TgAb (r = -0.150, p = 0.024) levels were correlated with serum 25(OH)D levels. Further multivariable logistic regression analyses suggested that the length of DM history, presence of hyperthyroidism, presence of hypothyroidism and positive TPOAb were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM.
UNASSIGNED: Hyperthyroidism, hypothyroidism and TPOAb positivity were significantly associated with the presence of 25(OH)D deficiency in postmenopausal women with T2DM.
摘要：
■在患有2型糖尿病的绝经后妇女中，25-羟维生素D（25（OH）D）水平与甲状腺疾病之间是否存在关联是未知的。本研究旨在探讨绝经后女性2型糖尿病(T2DM)患者血25(OH)D水平与甲状腺功能的关系。
这项横断面研究涉及中国绝经后妇女，她们于2021年3月至2022年5月到我们的糖尿病诊所就诊，并通过便利采样方法收集诊断为T2DM。从每个患者获得血液样本以检测血清促甲状腺激素（TSH），三碘甲状腺原氨酸（T3），甲状腺素(T4),自由T3（FT3），自由T4（FT4），甲状腺过氧化物酶抗体(TPOAb),甲状腺球蛋白抗体（TgAb）和25（OH）D水平。缺乏定义为25(OH)D<20ng/mL。比较分析采用t检验或卡方检验。然后使用Pearson相关性来估计不同甲状腺功能参数与25（OH）D之间的关系。采用多因素logistic回归分析探讨25(OH)D缺乏的危险因素。
■总共，230名参与者中有157名(68.26%)患有25(OH)D缺乏症。与25(OH)D水平正常的患者相比,25（OH）D缺乏症患者的糖尿病病史较短（DM，p=0.001）和更高的甲状腺功能亢进率（p=0.007），甲状腺功能减退（p<0.001），TPOAb阳性(p<0.001)和TgAb阳性(p<0.001)。相关分析表明,TSH(r=-0.144,p=0.030),FT4（r=-0.145，p=0.029），TPOAb(r=-0.216,p=0.001)和TgAb(r=-0.150,p=0.024)水平与血清25(OH)D水平相关。进一步的多变量逻辑回归分析表明，DM病史的长度，甲状腺功能亢进的存在，在绝经后T2DM患者中,甲状腺功能减退和TPOAb阳性与25(OH)D缺乏显著相关.
■甲状腺功能亢进，甲状腺功能减退和TPOAb阳性与绝经后T2DM患者25(OH)D缺乏显著相关。
这项横断面研究涉及中国绝经后妇女，她们于2021年3月至2022年5月到我们的糖尿病诊所就诊，并通过便利采样方法收集诊断为T2DM。从每个患者获得血液样本以检测血清促甲状腺激素（TSH），三碘甲状腺原氨酸（T3），甲状腺素(T4),自由T3（FT3），自由T4（FT4），甲状腺过氧化物酶抗体(TPOAb),甲状腺球蛋白抗体（TgAb）和25（OH）D水平。缺乏定义为25(OH)D<20ng/mL。比较分析采用t检验或卡方检验。然后使用Pearson相关性来估计不同甲状腺功能参数与25（OH）D之间的关系。采用多因素logistic回归分析探讨25(OH)D缺乏的危险因素。
■总共，230名参与者中有157名(68.26%)患有25(OH)D缺乏症。与25(OH)D水平正常的患者相比,25（OH）D缺乏症患者的糖尿病病史较短（DM，p=0.001）和更高的甲状腺功能亢进率（p=0.007），甲状腺功能减退（p<0.001），TPOAb阳性(p<0.001)和TgAb阳性(p<0.001)。相关分析表明,TSH(r=-0.144,p=0.030),FT4（r=-0.145，p=0.029），TPOAb(r=-0.216,p=0.001)和TgAb(r=-0.150,p=0.024)水平与血清25(OH)D水平相关。进一步的多变量逻辑回归分析表明，DM病史的长度，甲状腺功能亢进的存在，在绝经后T2DM患者中,甲状腺功能减退和TPOAb阳性与25(OH)D缺乏显著相关.
■甲状腺功能亢进，甲状腺功能减退和TPOAb阳性与绝经后T2DM患者25(OH)D缺乏显著相关。
