Abstract：
Melanoma has been reported in many parts of East Asia. However, there are no reports on the epidemiology of melanoma in Northeast China. In this study, we collected demographic, clinicopathologic, and treatment data of patients with melanoma treated at the First Hospital of Jilin University (Changchun, China). A total of 229 consecutive nonselective cases were analyzed for the incidence and clinicopathologic characteristics of melanoma. The median overall survival was 53.5 months. The 1-year, 3-year, and 5-year survival rates were 86.3, 66.4, and 44.8%, respectively. The median disease-free survival was 33.1 months, and the 1-year, 3-year, and 5-year disease-free survival rates were 75.0, 48.5, and 35.8%, respectively. Multivariate analysis showed that disease stage, Eastern Cooperative Oncology Group score, and lactic dehydrogenase were independent prognostic factors of overall survival. Pathologic subtype and stage were independent prognostic factors of disease-free survival. Furthermore, vascular invasion was a prognostic factor for overall survival in acral melanoma and a prognostic factor for disease-free survival in cutaneous melanoma. Compared with the Caucasian population, the population of Northeast China showed significant differences in disease location, pathologic subtype, gene status, and survival prognosis. In summary, our study showed that vascular invasion might be a prognostic factor in patients with acral and cutaneous melanoma.
摘要：
在东亚许多地区都有黑色素瘤的报道。然而,没有关于中国东北地区黑色素瘤流行病学的报道。在这项研究中,我们收集了人口统计，临床病理,以及在吉林大学第一医院治疗的黑色素瘤患者的治疗数据。共分析了229例连续非选择性黑色素瘤的发病率和临床病理特征。中位总生存期（OS）为53.5个月。1年,3年,5年生存率为86.3%,66.4%,和44.8%，分别。中位无病生存期(DFS)为33.1个月,和1年，3年,5年DFS率为75.0%，48.5%,和35.8%，分别。多因素分析显示,疾病分期,ECOG得分,LDH是OS的独立预后因素。病理亚型和分期是影响DFS的独立预后因素。此外，血管浸润是肢端黑色素瘤OS的预后因素,也是皮肤黑色素瘤DFS的预后因素.与高加索人口相比，东北地区人群在发病部位上表现出显著差异,病理亚型,基因状态，和生存预后。总之,我们的研究表明，血管侵犯可能是肢端和皮肤黑色素瘤患者的预后因素。
