PDF(Pubmed)
Abstract：
Resistance and tolerance are two important strategies employed by the host immune response to defend against pathogens. Multidrug-resistant bacteria affect the resistance mechanisms involved in pathogen clearance. Disease tolerance, defined as the ability to reduce the negative impact of infection on the host, might be a new research direction for the treatment of infections. The lungs are highly susceptible to infections and thus are important for understanding host tolerance and its precise mechanisms. This review focuses on the factors that induce lung disease tolerance, cell and molecular mechanisms involved in tissue damage control, and the relationship between disease tolerance and sepsis immunoparalysis. Understanding the exact mechanism of lung disease tolerance could allow better assessment of the immune status of patients and provide new ideas for the treatment of infections.
摘要：
抗性和耐受性是宿主免疫应答用于防御病原体的两种重要策略。多药耐药细菌影响病原体清除所涉及的耐药机制。抗病性,定义为减少感染对宿主的负面影响的能力，可能是治疗感染的一个新的研究方向。肺部极易感染，因此对于理解宿主耐受性及其精确机制很重要。这篇综述集中在诱发肺部疾病耐受性的因素，参与组织损伤控制的细胞和分子机制，以及疾病耐受性与脓毒症免疫麻痹的关系。了解肺部疾病耐受的确切机制可以更好地评估患者的免疫状态，为感染的治疗提供新思路。
