We describe an atypical case of relapsed RIAS after radical mastectomy, treated with new surgery and, considering the higher risk of recurrence, subsequent adjuvant chemotherapy with weekly paclitaxel.
The frequency of radiation-induced angiosarcomas (RIAS) after breast-conserving surgery and radiotherapy has been increased to 0.14-0.5% among long survivors. Nevertheless, even if RIAS continues to be prognostically an extremely unfavorable cancer due to a high rate of recurrence, distant spread, and median overall survival (OS) of about 60 months, the benefits of loco-regional breast radiotherapy are clearly higher than the risk in developing angiosarcoma.
方法:我们描述了一个在根治性乳房切除术后复发RIAS的非典型病例,接受新手术治疗,考虑到更高的复发风险,随后每周紫杉醇辅助化疗。
结论:在长期存活者中,保乳手术和放疗后放射诱导的血管肉瘤(RIAS)的发生率增加至0.14-0.5%。然而,即使RIAS由于高复发率而在预后上仍然是极其不利的癌症,遥远的传播,中位总生存期(OS)约为60个月,局部区域乳腺放疗的获益明显高于发生血管肉瘤的风险.