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Abstract：
To evaluate presence of perilimbal pigmentation (PLP) in Indian patients with vernal keratoconjunctivitis (VKC). Methods: A cross sectional study was conducted from 2019 to 2020 at a tertiary eye care center in Western Maharashtra, India. In this study, 152 cases of VKC were identified. The presence, type, color, and extent of PLP were recorded. The incidence of presence of PLP was calculated. Its correlations with severity and duration of VKC were analyzed using Wilcoxon-Mann-Whitney U test and Chi square test.
Of 152 cases, 79.61% were males. Mean age at presentation was 11.4 ± 5.6 years. The characteristic PLP was present in 81 cases (53.29%; 95% confidence interval [CI]: 45.03%-61.42%; P < 0.001), of which 15 cases (18.5%) had this pigmentation in all the four quadrants. There was a significant difference between the groups with respect to quadrants involvement in terms of the extent of PLP in clock hours (χ2 = 73.85, P < 0.001). However, the extent did not correlate with age (rho = 0.08, P = 0.487), sex (P = 0.115), time since onset in months (rho = 0.03, P = 0.77), duration of VKC and type or color of PLP (P = 0.12).
Perilimbal pigmentation seems to be a consistent clinical finding seen in a significant number of VKC cases. It may benefit ophthalmologists in treating VKC cases when the palpebral/limbal signs are elusive.
Of 152 cases, 79.61% were males. Mean age at presentation was 11.4 ± 5.6 years. The characteristic PLP was present in 81 cases (53.29%; 95% confidence interval [CI]: 45.03%-61.42%; P < 0.001), of which 15 cases (18.5%) had this pigmentation in all the four quadrants. There was a significant difference between the groups with respect to quadrants involvement in terms of the extent of PLP in clock hours (χ2 = 73.85, P < 0.001). However, the extent did not correlate with age (rho = 0.08, P = 0.487), sex (P = 0.115), time since onset in months (rho = 0.03, P = 0.77), duration of VKC and type or color of PLP (P = 0.12).
Perilimbal pigmentation seems to be a consistent clinical finding seen in a significant number of VKC cases. It may benefit ophthalmologists in treating VKC cases when the palpebral/limbal signs are elusive.
摘要：
■评估印度春季角膜结膜炎（VKC）患者的外周色素沉着（PLP）的存在。方法：2019年至2020年，在西马哈拉施特拉邦的三级眼科护理中心进行了一项横断面研究，印度。在这项研究中,发现152例VKC。的存在，type,颜色,记录PLP的程度。计算PLP存在的发生率。使用Wilcoxon-Mann-WhitneyU检验和卡方检验分析其与VKC严重程度和持续时间的相关性。
■在152个案例中，79.61%为男性。演示时的平均年龄为11.4±5.6岁。81例患者存在特征性PLP(53.29%;95%置信区间[CI]:45.03%-61.42%;P<0.001),其中15例(18.5%)在所有四个象限都有这种色素沉着。就时钟时间的PLP程度而言，两组之间在象限参与方面存在显着差异（χ2=73.85，P<0.001）。然而,程度与年龄无关(rho=0.08,P=0.487),性别（P=0.115），发病时间以月为单位(rho=0.03，P=0.77)，VKC的持续时间和PLP的类型或颜色(P=0.12)。
■Perilimbal色素沉着似乎是在大量VKC病例中观察到的一致的临床发现。当眼睑/角膜缘体征难以捉摸时，它可能有益于眼科医生治疗VKC病例。
■在152个案例中，79.61%为男性。演示时的平均年龄为11.4±5.6岁。81例患者存在特征性PLP(53.29%;95%置信区间[CI]:45.03%-61.42%;P<0.001),其中15例(18.5%)在所有四个象限都有这种色素沉着。就时钟时间的PLP程度而言，两组之间在象限参与方面存在显着差异（χ2=73.85，P<0.001）。然而,程度与年龄无关(rho=0.08,P=0.487),性别（P=0.115），发病时间以月为单位(rho=0.03，P=0.77)，VKC的持续时间和PLP的类型或颜色(P=0.12)。
■Perilimbal色素沉着似乎是在大量VKC病例中观察到的一致的临床发现。当眼睑/角膜缘体征难以捉摸时，它可能有益于眼科医生治疗VKC病例。
