PDF(Pubmed)
Abstract：
BACKGROUND: Primary thyroid lymphoma (PTL) is a rare cancer accounting for approximately 5% of thyroid malignancies. Historically, incisional biopsy has been the gold standard for definitive diagnosis of PTL, however, the use of cell block as an adjunct to fine needle aspiration (FNA) provides a high sensitivity and specificity for diagnosis and classification.
METHODS: Three patients presented with a symptomatic enlarging thyroid mass. Patient 1 underwent incisional biopsy under general anesthesia, Patient 2 underwent core needle biopsy to avoid high risk intubation, and Patient 3 underwent fine needle aspiration alone with the use of cell block.
RESULTS: All patients were diagnosed with a fully classified non-Hodgkin\'s lymphoma using immunohistochemistry, flow cytometry, and fluorescence in situ hybridization (FISH) analysis.
CONCLUSIONS: FNA for diagnosis of some subtypes of PTL is feasible and preferred in cases that are particularly high risk for general anesthesia. This minimally invasive technique is safe and cost effective as it avoids expenses associated with operative intervention.
METHODS: Three patients presented with a symptomatic enlarging thyroid mass. Patient 1 underwent incisional biopsy under general anesthesia, Patient 2 underwent core needle biopsy to avoid high risk intubation, and Patient 3 underwent fine needle aspiration alone with the use of cell block.
RESULTS: All patients were diagnosed with a fully classified non-Hodgkin\'s lymphoma using immunohistochemistry, flow cytometry, and fluorescence in situ hybridization (FISH) analysis.
CONCLUSIONS: FNA for diagnosis of some subtypes of PTL is feasible and preferred in cases that are particularly high risk for general anesthesia. This minimally invasive technique is safe and cost effective as it avoids expenses associated with operative intervention.
摘要：
背景：原发性甲状腺淋巴瘤（PTL）是一种罕见的癌症，约占甲状腺恶性肿瘤的5％。历史上,切开活检一直是明确诊断PTL的金标准，然而,使用细胞块作为细针抽吸术(FNA)的辅助手段,为诊断和分类提供了较高的敏感性和特异性.
方法：3例患者表现为症状性甲状腺肿块增大。患者1在全身麻醉下进行了切开活检，患者2接受了芯针活检以避免高风险插管，和患者3单独使用细胞块进行细针抽吸。
结果：所有患者均使用免疫组织化学诊断为完全分类的非霍奇金淋巴瘤，流式细胞术,和荧光原位杂交（FISH）分析。
结论：FNA用于诊断某些PTL亚型是可行的，并且在全身麻醉风险特别高的情况下是优选的。这种微创技术是安全且成本有效的,因为它避免了与手术干预相关的费用。
方法：3例患者表现为症状性甲状腺肿块增大。患者1在全身麻醉下进行了切开活检，患者2接受了芯针活检以避免高风险插管，和患者3单独使用细胞块进行细针抽吸。
结果：所有患者均使用免疫组织化学诊断为完全分类的非霍奇金淋巴瘤，流式细胞术,和荧光原位杂交（FISH）分析。
结论：FNA用于诊断某些PTL亚型是可行的，并且在全身麻醉风险特别高的情况下是优选的。这种微创技术是安全且成本有效的,因为它避免了与手术干预相关的费用。
