关键词: C57BL6 mice Rosmarinus officinalis flavonoids hair follicles herbal formulation minoxidil skin pigmentation

来  源:   DOI:10.4103/abr.abr_306_21   PDF(Pubmed)

Abstract:
UNASSIGNED: Rosmarinus officinalis (rosemary) is a common household plant with needle-like leaves and white flowers that belongs to the family Lamiaceae and has various medicinal properties including ailments of hair and scalp, cardiovascular, nervous disorders, etc., In the current work, we have focused on formulation and evaluation of 1% hair lotion incorporated with methanolic extract of R. officinalis.
UNASSIGNED: The aerial parts of the plant were extracted with methanol and then the nature of phytochemicals were identified by chemical tests. It showed the presence of proteins, amino acids, fats and oils, steroids, glycosides, phenolic compounds, flavonoids, volatile oil, and vitamins. The extract was formulated to a suitable hair lotion and then evaluated for its various quality control parameters. Finally, the lotion was evaluated for hair growth promoting activity on C57BL/6 mice, using water as control and 2% minoxidil hair lotion as standard.
UNASSIGNED: It was observed that the formulated 1% herbal hair lotion passed all the evaluation parameters and showed a significant hair growth promoting activity than the standard drug-treated animals.
UNASSIGNED: Although several researches have been carried out on the rosemary, an investigation on formulation of hair lotion adding the extract of the aerial part of the plant is for the first time. Since our formulation exhibited an excellent activity, it can be well thought out to be an alternative to the commercially available hair growth promoters with a lot of unwanted effects.
摘要:
迷迭香(迷迭香)是一种常见的家用植物,具有针状叶子和白色花朵,属于唇形科,具有多种药用特性,包括头发和头皮疾病,心血管,神经紊乱,等。,在目前的工作中,我们专注于配制和评估1%的头发洗液中掺入了R.officinalis的甲醇提取物。
用甲醇提取植物的地上部分,然后通过化学测试鉴定植物化学物质的性质。它显示了蛋白质的存在,氨基酸,脂肪和油,类固醇,糖苷,酚类化合物,黄酮类化合物,挥发油,和维生素。将提取物配制成合适的毛发洗剂,然后评价其各种质量控制参数。最后,评估洗剂对C57BL/6小鼠的毛发生长促进活性,使用水作为对照和2%米诺地尔润发液作为标准。
观察到配制的1%草本毛发洗剂通过了所有评价参数,并且显示出比标准药物处理的动物显著的毛发生长促进活性。
尽管已经对迷迭香进行了一些研究,首次对添加植物地上部分提取物的护发液配方进行研究。由于我们的配方表现出优异的活性,它可以很好地认为是一种替代市售的头发生长促进剂有很多不想要的效果。
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