PDF(Pubmed)
Abstract：
UNASSIGNED: Tai Chi Chuan (TCC) may have a positive impact on physical and psychological well-being in breast cancer patients, but the evidence remains limited and inconclusive. This systematic review aims to evaluate the effects of TCC on the quality of life (QoL) and psychological symptoms in women patients with breast cancer.
UNASSIGNED: This review has been registered on PROSPERO (ID: CRD42019141977). Randomized controlled trials (RCTs) of TCC for breast cancer were searched from eight major English and Chinese databases. All trials included were analyzed in accordance with the Cochrane Handbook. The primary outcomes were QoL, anxiety, and depression in patients with breast cancer. Fatigue, sleep quality, cognitive function, and inflammatory cytokine were the secondary outcomes.
UNASSIGNED: Fifteen RCTs involving a total of 1,156 breast cancer participants were included in this review. The methodological quality of included trials was generally poor. The pooled results suggested that TCC-based exercise could significantly improve QoL [standardized mean difference (SMD)=0.35, 95%CI: 0.15-0.55, I 2 = 0, model: fixed, IV], anxiety [weighted mean difference (WMD)=-4.25, 95%CI: -5.88 to -2.63, I 2 = 0, model: fixed, IV], and fatigue (SMD=-0.87, 95%CI: -1.50 to -0.24, I 2 = 80.9%, model: random, DL) compared other controls, with moderate to low certainty of evidence. The improvement of QoL and fatigue by TCC was also clinically meaningful. However, TCC-based exercise failed to show any between-group differences in depression, sleep quality, cognitive function, and inflammatory cytokine. Post-hoc analysis revealed that TCC-based exercise outperformed the other exercise in improving shoulder function with very low certainty of evidence.
UNASSIGNED: Our findings manifested that TCC-based exercise is helpful for improving the QoL, anxiety, and fatigue in patients with breast cancer within the range of comparisons covered in this study. However, the results must be treated with great caution because of the methodological flaws of included trials. Larger, well-designed, and conducted randomized controlled trials with longer follow-up is warranted in the future to evaluate the important outcomes of TCC for breast cancer.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019141977, identifier, CRD42019141977.
UNASSIGNED: This review has been registered on PROSPERO (ID: CRD42019141977). Randomized controlled trials (RCTs) of TCC for breast cancer were searched from eight major English and Chinese databases. All trials included were analyzed in accordance with the Cochrane Handbook. The primary outcomes were QoL, anxiety, and depression in patients with breast cancer. Fatigue, sleep quality, cognitive function, and inflammatory cytokine were the secondary outcomes.
UNASSIGNED: Fifteen RCTs involving a total of 1,156 breast cancer participants were included in this review. The methodological quality of included trials was generally poor. The pooled results suggested that TCC-based exercise could significantly improve QoL [standardized mean difference (SMD)=0.35, 95%CI: 0.15-0.55, I 2 = 0, model: fixed, IV], anxiety [weighted mean difference (WMD)=-4.25, 95%CI: -5.88 to -2.63, I 2 = 0, model: fixed, IV], and fatigue (SMD=-0.87, 95%CI: -1.50 to -0.24, I 2 = 80.9%, model: random, DL) compared other controls, with moderate to low certainty of evidence. The improvement of QoL and fatigue by TCC was also clinically meaningful. However, TCC-based exercise failed to show any between-group differences in depression, sleep quality, cognitive function, and inflammatory cytokine. Post-hoc analysis revealed that TCC-based exercise outperformed the other exercise in improving shoulder function with very low certainty of evidence.
UNASSIGNED: Our findings manifested that TCC-based exercise is helpful for improving the QoL, anxiety, and fatigue in patients with breast cancer within the range of comparisons covered in this study. However, the results must be treated with great caution because of the methodological flaws of included trials. Larger, well-designed, and conducted randomized controlled trials with longer follow-up is warranted in the future to evaluate the important outcomes of TCC for breast cancer.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42019141977, identifier, CRD42019141977.
摘要：
■太极拳（TCC）可能对乳腺癌患者的身心健康产生积极影响，但是证据仍然有限，没有定论。本系统综述旨在评估TCC对女性乳腺癌患者生活质量（QoL）和心理症状的影响。
■此评论已在PROSPERO上注册（ID：CRD42019141977）。从八个主要的英文和中文数据库中检索TCC治疗乳腺癌的随机对照试验（RCT）。根据Cochrane手册分析包括的所有试验。主要结果是QoL，焦虑,和乳腺癌患者的抑郁症。疲劳,睡眠质量,认知功能,和炎性细胞因子是次要结局。
■15项RCT纳入本综述，涉及1,156名乳腺癌参与者。纳入试验的方法学质量普遍较差。汇总结果表明，基于TCC的运动可以显着改善QoL[标准化平均差（SMD）=0.35，95CI：0.15-0.55，I2=0，模型：固定，IV],焦虑[加权平均差（WMD）=-4.25，95CI：-5.88至-2.63，I2=0，模型：固定，IV],和疲劳（SMD=-0.87，95CI：-1.50至-0.24，I2=80.9%，型号：随机，DL)与其他对照相比，具有中等到低的证据确定性。TCC改善QoL和疲劳也具有临床意义。然而,基于TCC的运动未能显示出抑郁症的任何组间差异，睡眠质量,认知功能,和炎性细胞因子。事后分析显示，基于TCC的运动在改善肩部功能方面优于其他运动，证据的确定性非常低。
■我们的发现表明，基于TCC的运动有助于改善QoL，焦虑,在本研究涵盖的比较范围内，乳腺癌患者的疲劳感。然而,由于纳入试验的方法学缺陷,必须非常谨慎地对待结果.较大,精心设计,未来有必要进行随机对照试验,随访时间更长,以评估TCC治疗乳腺癌的重要结局.
■https://www.crd.约克。AC.uk/prospro/display_record.php？ID=CRD42019141977，标识符，CRD42019141977.
■此评论已在PROSPERO上注册（ID：CRD42019141977）。从八个主要的英文和中文数据库中检索TCC治疗乳腺癌的随机对照试验（RCT）。根据Cochrane手册分析包括的所有试验。主要结果是QoL，焦虑,和乳腺癌患者的抑郁症。疲劳,睡眠质量,认知功能,和炎性细胞因子是次要结局。
■15项RCT纳入本综述，涉及1,156名乳腺癌参与者。纳入试验的方法学质量普遍较差。汇总结果表明，基于TCC的运动可以显着改善QoL[标准化平均差（SMD）=0.35，95CI：0.15-0.55，I2=0，模型：固定，IV],焦虑[加权平均差（WMD）=-4.25，95CI：-5.88至-2.63，I2=0，模型：固定，IV],和疲劳（SMD=-0.87，95CI：-1.50至-0.24，I2=80.9%，型号：随机，DL)与其他对照相比，具有中等到低的证据确定性。TCC改善QoL和疲劳也具有临床意义。然而,基于TCC的运动未能显示出抑郁症的任何组间差异，睡眠质量,认知功能,和炎性细胞因子。事后分析显示，基于TCC的运动在改善肩部功能方面优于其他运动，证据的确定性非常低。
■我们的发现表明，基于TCC的运动有助于改善QoL，焦虑,在本研究涵盖的比较范围内，乳腺癌患者的疲劳感。然而,由于纳入试验的方法学缺陷,必须非常谨慎地对待结果.较大,精心设计,未来有必要进行随机对照试验,随访时间更长,以评估TCC治疗乳腺癌的重要结局.
■https://www.crd.约克。AC.uk/prospro/display_record.php？ID=CRD42019141977，标识符，CRD42019141977.
