PDF(Pubmed)
Abstract：
UNASSIGNED: Stroke has been considered to raise the risk of dementia in several studies, but the relationship between brain structural changes and poststroke cognitive impairment (PSCI) is unclear.
UNASSIGNED: In this study, 23 PSCI patients with basal ganglia infarcts after 2 weeks and 29 age-matched controls underwent magnetic resonance imaging measuring cortical thickness and volume changes, as well as neuropsychological tests. CI was derived from a performance score <1.5 standard deviations for normally distributed scores. We compared Z scores in different cognitive domains and cortical thickness and volumes in two groups. Multiple linear regressions were used to investigate the relationship between cortical thickness and volumes and neuropsychological tests.
UNASSIGNED: A majority of PSCI patients were in their 50s (55.19±8.52 years). PSCI patients exhibited significantly decreased Z scores in multiple domains, such as memory, language, visuomotor speed, and attention/executive function. The volumes of the middle posterior corpus callosum, middle anterior corpus callosum, and hippocampus in PSCI patients were markedly lower than controls. The thickness of the right inferior temporal cortex and insula were significantly smaller than controls. It found that the reduced right hippocampus was related to executive dysfunction. Hippocampus dysfunction may be involved in language impairment (p<0.05) in PSCI patients with basal ganglia infarcts.
UNASSIGNED: These findings demonstrated that brain structure changed after ischemic stroke, and different gray-matter structural changes could lead to specific cognitive decline in PSCI patients with basal ganglia infarcts. Atrophy of the right hippocampus potentially serves as an imaging marker of early executive function of PSCI.
UNASSIGNED: In this study, 23 PSCI patients with basal ganglia infarcts after 2 weeks and 29 age-matched controls underwent magnetic resonance imaging measuring cortical thickness and volume changes, as well as neuropsychological tests. CI was derived from a performance score <1.5 standard deviations for normally distributed scores. We compared Z scores in different cognitive domains and cortical thickness and volumes in two groups. Multiple linear regressions were used to investigate the relationship between cortical thickness and volumes and neuropsychological tests.
UNASSIGNED: A majority of PSCI patients were in their 50s (55.19±8.52 years). PSCI patients exhibited significantly decreased Z scores in multiple domains, such as memory, language, visuomotor speed, and attention/executive function. The volumes of the middle posterior corpus callosum, middle anterior corpus callosum, and hippocampus in PSCI patients were markedly lower than controls. The thickness of the right inferior temporal cortex and insula were significantly smaller than controls. It found that the reduced right hippocampus was related to executive dysfunction. Hippocampus dysfunction may be involved in language impairment (p<0.05) in PSCI patients with basal ganglia infarcts.
UNASSIGNED: These findings demonstrated that brain structure changed after ischemic stroke, and different gray-matter structural changes could lead to specific cognitive decline in PSCI patients with basal ganglia infarcts. Atrophy of the right hippocampus potentially serves as an imaging marker of early executive function of PSCI.
摘要：
■在一些研究中，中风被认为会增加痴呆的风险，但大脑结构改变与卒中后认知障碍(PSCI)之间的关系尚不清楚。
■在这项研究中，2周后23例PSCI基底神经节梗死患者和29例年龄匹配的对照者接受磁共振成像测量皮质厚度和体积变化，以及神经心理学测试。CI来源于正态分布得分的表现得分<1.5个标准差。我们比较了两组不同认知域的Z评分以及皮质厚度和体积。使用多元线性回归来研究皮质厚度与体积之间的关系以及神经心理学测试。
■大多数PSCI患者年龄在50多岁（55.19±8.52岁）。PSCI患者在多个领域表现出显著降低的Z评分，比如记忆，语言,视觉运动速度，和注意力/执行功能。后部中体的体积，中前call体，PSCI患者海马明显低于对照组。右侧颞下皮质和脑岛的厚度明显小于对照组。发现右海马减少与执行功能障碍有关。海马功能障碍可能与PSCI患者基底节梗死的语言障碍有关（p<0.05）。
■这些研究结果表明，缺血性卒中后大脑结构发生了改变，不同的灰质结构改变可能导致PSCI患者基底神经节梗死的特异性认知功能下降。右海马萎缩可能是PSCI早期执行功能的成像标记。
■在这项研究中，2周后23例PSCI基底神经节梗死患者和29例年龄匹配的对照者接受磁共振成像测量皮质厚度和体积变化，以及神经心理学测试。CI来源于正态分布得分的表现得分<1.5个标准差。我们比较了两组不同认知域的Z评分以及皮质厚度和体积。使用多元线性回归来研究皮质厚度与体积之间的关系以及神经心理学测试。
■大多数PSCI患者年龄在50多岁（55.19±8.52岁）。PSCI患者在多个领域表现出显著降低的Z评分，比如记忆，语言,视觉运动速度，和注意力/执行功能。后部中体的体积，中前call体，PSCI患者海马明显低于对照组。右侧颞下皮质和脑岛的厚度明显小于对照组。发现右海马减少与执行功能障碍有关。海马功能障碍可能与PSCI患者基底节梗死的语言障碍有关（p<0.05）。
■这些研究结果表明，缺血性卒中后大脑结构发生了改变，不同的灰质结构改变可能导致PSCI患者基底神经节梗死的特异性认知功能下降。右海马萎缩可能是PSCI早期执行功能的成像标记。
