Abstract：
Each year, thousands of people suffer from traumatic peripheral nerve lesions, which impair mobility and sensibility and frequently have fatal outcomes. The recovery of peripheral nerves on its own is frequently insufficient. In this regard, cell therapy is currently one of the most cutting-edge techniques for nerve healing. The purpose of this review is to highlight the properties of various types of mesenchymal stem cells (MSCs) that are critical for peripheral nerve regeneration after nerve injury. The Preferred Reporting term used to review the available literature are \"nerve regeneration,\" \"stem cells,\" \"peripheral nerve damage,\" \"rat,\" and \"human\" were combined. In addition, using the phrases \"stem cells\" and \"nerve regeneration\" in PubMed, a \"MeSH\" search was conducted. This study describes the features of the most often utilized MSCs, as well as its paracrine potential, targeted stimulation, and propensity for differentiation into Schwann-like and neuronal-like cells. For the repair of peripheral nerve lesions, ADSCs appear to be the most relevant and promising MSCs, because of their ability to sustain and increase axonal growth, as well as their outstanding paracrine activity, putative differentiation potential, low immunogenicity, and excellent post-transplant survival rate.
摘要：
每一年,成千上万的人患有创伤性周围神经病变，损害流动性和敏感性，并经常有致命的结果。周围神经自身的恢复通常是不够的。在这方面,细胞疗法是目前最尖端的神经愈合技术之一。这篇综述的目的是强调各种类型的间充质干细胞（MSCs）的特性，这些干细胞对于神经损伤后的周围神经再生至关重要。用于审查现有文献的首选报告术语是“神经再生，干细胞，周围神经损伤，\"\"老鼠,“”和“人类”结合在一起。此外,使用PubMed中的短语“干细胞”和“神经再生”，进行了“MeSH”搜索。这项研究描述了最常用的MSC的特征，以及它的旁分泌潜能，有针对性的刺激,和分化为雪旺样和神经元样细胞的倾向。对于周围神经损伤的修复，ADSCs似乎是最相关和最有前途的MSCs，因为它们有能力维持和增加轴突生长，以及他们出色的旁分泌活动，推定的分化潜力，低免疫原性,和优秀的移植后存活率。
