Abstract：
OBJECTIVE: This study aimed to evaluate the recovery of olfactory function at six months in individuals infected with the coronavirus disease 2019 omicron variant, using psychophysical tests.
METHODS: A prospective case-control study that included severe acute respiratory syndrome coronavirus-2 patients infected in February and March 2022 was conducted. Patients underwent the Sniffin\' Sticks test within 10 days of infection and again after at least 6 months. The olfactory scores were compared with those of a control group.
RESULTS: In all, 102 patients and 120 controls were enrolled in the study. At baseline, 26 patients (25.5 per cent) self-reported smell loss. The median threshold, discrimination and identification score was 33.6 (interquartile range, 12.5) for the cases and 36.5 (interquartile range, 4.38) for the controls (p < 0.001). Based on the threshold, discrimination and identification scores, 12 controls and 34 patients reported olfactory dysfunction (p < 0.001). Eighty cases underwent re-evaluation at six months; the median threshold, discrimination and identification score was 37.1 (interquartile range, 4.75) with no significant differences compared with the controls.
CONCLUSIONS: Six months after infection, the prevalence of olfactory dysfunction in patients did not differ significantly from the control population.
METHODS: A prospective case-control study that included severe acute respiratory syndrome coronavirus-2 patients infected in February and March 2022 was conducted. Patients underwent the Sniffin\' Sticks test within 10 days of infection and again after at least 6 months. The olfactory scores were compared with those of a control group.
RESULTS: In all, 102 patients and 120 controls were enrolled in the study. At baseline, 26 patients (25.5 per cent) self-reported smell loss. The median threshold, discrimination and identification score was 33.6 (interquartile range, 12.5) for the cases and 36.5 (interquartile range, 4.38) for the controls (p < 0.001). Based on the threshold, discrimination and identification scores, 12 controls and 34 patients reported olfactory dysfunction (p < 0.001). Eighty cases underwent re-evaluation at six months; the median threshold, discrimination and identification score was 37.1 (interquartile range, 4.75) with no significant differences compared with the controls.
CONCLUSIONS: Six months after infection, the prevalence of olfactory dysfunction in patients did not differ significantly from the control population.
摘要：
目的：本研究旨在评估感染冠状病毒病2019omicron变种的个体在六个月时嗅觉功能的恢复，使用心理物理测试。
方法：进行了一项前瞻性病例对照研究，包括2022年2月和3月感染的严重急性呼吸综合征冠状病毒-2患者。患者在感染后10天内接受Sniffin\'Sticks测试，并在至少6个月后再次接受。将嗅觉评分与对照组进行比较。
结果：总而言之，102名患者和120名对照者被纳入研究。在基线,26名患者(25.5%)自我报告嗅觉丧失。中位数阈值，辨别和识别得分为33.6(四分位数间距，12.5)的情况和36.5(四分位数间距，4.38)用于对照(p<0.001)。根据阈值，歧视和识别分数，12名对照和34名患者报告嗅觉功能障碍(p<0.001)。80例接受了六个月的重新评估；中位数阈值，辨别和识别得分为37.1分(四分位数间距，4.75)与对照组相比无显著性差异。
结论：感染后六个月，患者嗅觉功能障碍的患病率与对照组无显著差异.
方法：进行了一项前瞻性病例对照研究，包括2022年2月和3月感染的严重急性呼吸综合征冠状病毒-2患者。患者在感染后10天内接受Sniffin\'Sticks测试，并在至少6个月后再次接受。将嗅觉评分与对照组进行比较。
结果：总而言之，102名患者和120名对照者被纳入研究。在基线,26名患者(25.5%)自我报告嗅觉丧失。中位数阈值，辨别和识别得分为33.6(四分位数间距，12.5)的情况和36.5(四分位数间距，4.38)用于对照(p<0.001)。根据阈值，歧视和识别分数，12名对照和34名患者报告嗅觉功能障碍(p<0.001)。80例接受了六个月的重新评估；中位数阈值，辨别和识别得分为37.1分(四分位数间距，4.75)与对照组相比无显著性差异。
结论：感染后六个月，患者嗅觉功能障碍的患病率与对照组无显著差异.
