PDF(Pubmed)
Abstract：
Considerable evidence points to a dominant role of inflammation in tumor pathology. The biological response of the immune system can be triggered by Toxoplasma gondii as a common brain-tropic parasite. The aim of this study was to investigate an association between Toxoplasma infection and brain tumors. This case-control study was performed on sera of brain tumor patients (n = 124) and age- and sex-matched control subjects (n = 124) in Southern Iran. Data related to tumor site and type were collected during sample collection. Anti-Toxoplasma IgG was assessed by enzyme-linked immunosorbent assay (ELISA). Seroprevalence anti-Toxoplasma IgG was significantly higher in brain tumor patients 30.6% (38/124) compared with 12.1% (15/124) of the healthy controls (OR 3.211; 95% CI 1.658 to 6.219; p = 0.001). The highest seroprevalence was detected in patients with ependymoma (100%), followed by glioblastoma (83%), pituitary adenoma (47.3%), astrocytoma (27.2%), schwannoma (23%), and meningioma (22.6%). The parasite infection was correlated to brain tumor\'s location i.e., the patients with frontal lobe and sella region tumors had higher seropositivity compared with others (P < 0.05). The higher prevalence of Toxoplasma infection among patients with brain tumor compared with the control group indicates a probable association between the infection and brain tumors.
摘要：
相当多的证据表明炎症在肿瘤病理学中起主导作用。弓形虫作为一种常见的嗜脑寄生虫可以触发免疫系统的生物反应。这项研究的目的是研究弓形虫感染与脑肿瘤之间的关系。这项病例对照研究是对伊朗南部脑肿瘤患者（n=124）以及年龄和性别匹配的对照受试者（n=124）的血清进行的。在样品收集期间收集与肿瘤部位和类型相关的数据。通过酶联免疫吸附测定（ELISA）评估抗弓形虫IgG。脑肿瘤患者中抗弓形虫IgG血清阳性率明显高于30.6%(38/124)，而健康对照组为12.1%(15/124)(OR3.211;95%CI1.658至6.219;p=0.001)。在室管膜瘤患者中检测到最高的血清阳性率（100％），其次是胶质母细胞瘤（83%），垂体腺瘤（47.3%），星形细胞瘤(27.2%),神经鞘瘤(23%)，和脑膜瘤(22.6%)。寄生虫感染与脑肿瘤的位置相关，即，额叶和鞍区肿瘤患者的血清阳性率高于其他患者（P<0.05）。与对照组相比，脑肿瘤患者弓形虫感染率较高，表明感染与脑肿瘤之间可能存在关联。
