Abstract：
Many studies have suggested an association between 9p24 rs719725 polymorphism and colorectal cancer (CRC) risk, but with inconsistent results. This meta-analysis aimed to summarise the overall association of rs719725 polymorphism with CRC risk. Nine eligible articles with 21 case-control studies (16015 CRC patients and 19341 controls) on the rs719725 polymorphism and CRC susceptibility from four electronic databases (Web of Science, PubMed, SinoMed, and EMBASE) were retrieved and analysed. The association was evaluated with publication bias, pooled OR (odds ratio), and corresponding 95% CI (confidence interval). The pooled results indicated a significant association between the increased CRC risk and rs719725 polymorphism in dominant ([OR] 1.220, [95%CI] 1.161-1.282), recessive (1.166, 1.102-1.234), allele (1.142, 1.102-1.184), homozygous (1.306, 1.212-1.406), and heterozygous (1.18, 1.129-1.234) genetic models. The ethnicity-stratified analyses found a consistently significant association. In the stratification analysis with the source of controls, such significant association was also detected amid the population-based studies under the four former genetic models. Taken together, this meta-analysis indicates that rs719725 genetic variants are associated with an increased risk of CRC among Caucasians and population-based studies. Further relevant research is warranted to confirm these findings. Key Words: Colorectal cancer, rs719725, Polymorphism, Meta-analysis, Stratification analysis.
摘要：
许多研究表明9p24rs719725多态性与结直肠癌（CRC）风险之间存在关联。但结果不一致。这项荟萃分析旨在总结rs719725多态性与CRC风险的总体关联。来自四个电子数据库（WebofScience，PubMed,SinoMed,和EMBASE)进行了检索和分析。该关联与发表偏倚进行了评估，合并OR(赔率比)，和相应的95%CI(置信区间)。汇总结果表明，CRC风险增加与显性rs719725多态性之间存在显着关联（[OR]1.220，[95CI]1.161-1.282），隐性（1.166，1.102-1.234），等位基因（1.142，1.102-1.184），纯合（1.306，1.212-1.406），和杂合(1.18，1.129-1.234)遗传模型。种族分层分析发现了一致的显着关联。在具有控制源的分层分析中，在前4种遗传模型下的基于人群的研究中,也发现了这种显著的相关性.一起来看,这项荟萃分析显示,在白种人和基于人群的研究中,rs719725遗传变异与CRC风险增加相关.需要进一步的相关研究来证实这些发现。关键词:结直肠癌,rs719725,多态性,Meta分析,分层分析。
