PDF(Pubmed)
Abstract：
The choice of the most appropriate suture threads for pancreatic anastomoses may play an important role in reducing the incidence of post-operative pancreatic fistula (POPF). The literature on this topic is still not conclusive. The aim of this study was to analyze the mechanical characteristics of suture materials to find the best suture threads for pancreatic anastomoses. A single-axial electromagnetic actuation machine was used to obtain the stress-deformation relationship curves and to measure both the ultimate tensile strength (UTS) and the Young\'s modulus at the 0-3% deformation range (E0-3) of four different suture materials (Poliglecaprone 25, Polydioxanone, Polyglactin 910, and Polypropylene) at baseline and after incubation in saline solution, bile, and pancreatic juice for 1, 3, and 7 days. Polydioxanone and Polypropylene showed stable values of UTS and E0-3 in all conditions. Polyglactin 910 presented significant UTS and E0-3 variations between different time intervals in all types of liquids analyzed. Poliglecaprone 25 lost half of its strength in all biological liquids analyzed but maintained low E0-3 values, which could reduce the risk of lacerations of soft tissues. These results suggest that Polydioxanone and Poliglecaprone 25 could be the best suture materials to use for pancreatic anastomoses. In vivo experiments will be organized to obtain further confirmations of this in vitro evidence.
摘要：
选择最合适的缝合线进行胰腺吻合术可能在减少术后胰瘘（POPF）的发生率中起重要作用。关于这一主题的文献仍然没有定论。这项研究的目的是分析缝合材料的力学特性，以找到用于胰腺吻合的最佳缝合线。使用单轴电磁致动机来获得应力-变形关系曲线，并在0-3％变形范围（E0-3）下测量极限抗拉强度（UTS）和杨氏模量四种不同的缝合线材料（Poliglecaprone25，聚二恶烷酮，Polyglactin910和聚丙烯)在基线和在盐溶液中孵育后，胆汁,和胰液1、3和7天。聚二恶烷酮和聚丙烯在所有条件下都显示出稳定的UTS和E0-3值。Polyglactin910在所分析的所有类型的液体中的不同时间间隔之间呈现显著的UTS和E0-3变化。Poligecaprone25在所有分析的生物液体中失去一半的强度，但保持较低的E0-3值，这可以降低软组织撕裂的风险。这些结果表明，聚二恶烷酮和Poliglecaprone25可能是用于胰腺吻合的最佳缝合材料。将组织体内实验以获得该体外证据的进一步确认。
