PDF(Pubmed)
Abstract：
Translocator protein (TSPO) is a neuroinflammation hallmark. Different TSPO affinity compounds have been produced and over time, the techniques of radiolabeling have been refined. The aim of this systematic review is to summarize the development of new radiotracers for dementia and neuroinflammation imaging.
An online search of the literature was conducted in the PubMed, Scopus, Medline, Cochrane Library, and Web of Science databases, selecting published studies from January 2004 to December 2022. The accepted studies considered the synthesis of TSPO tracers for nuclear medicine imaging in dementia and neuroinflammation.
A total of 50 articles was identified. Twelve papers were selected from the included studies\' bibliographies and 34 were excluded. Thus, 28 articles were ultimately selected for quality assessment.
Huge efforts in developing specific and stable tracers for PET/SPECT imaging have been made. The long half-life of 18F makes this isotope a preferable choice to 11C. An emerging limitation to this however is that neuroinflammation involves all of the brain which inhibits the possibility of detecting a slight inflammation status change in patients. A partial solution to this is using the cerebellum as a reference region and developing higher TSPO affinity tracers. Moreover, it is necessary to consider the presence of distomers and racemic compounds interfering with pharmacological tracers\' effects and increasing the noise ratio in images.
An online search of the literature was conducted in the PubMed, Scopus, Medline, Cochrane Library, and Web of Science databases, selecting published studies from January 2004 to December 2022. The accepted studies considered the synthesis of TSPO tracers for nuclear medicine imaging in dementia and neuroinflammation.
A total of 50 articles was identified. Twelve papers were selected from the included studies\' bibliographies and 34 were excluded. Thus, 28 articles were ultimately selected for quality assessment.
Huge efforts in developing specific and stable tracers for PET/SPECT imaging have been made. The long half-life of 18F makes this isotope a preferable choice to 11C. An emerging limitation to this however is that neuroinflammation involves all of the brain which inhibits the possibility of detecting a slight inflammation status change in patients. A partial solution to this is using the cerebellum as a reference region and developing higher TSPO affinity tracers. Moreover, it is necessary to consider the presence of distomers and racemic compounds interfering with pharmacological tracers\' effects and increasing the noise ratio in images.
摘要：
背景：转运蛋白（TSPO）是一种神经炎症标志。已经产生了不同的TSPO亲和化合物，并且随着时间的推移，放射性标记的技术已经完善。本系统综述的目的是总结用于痴呆和神经炎症成像的新型放射性示踪剂的发展。
方法：在PubMed，Scopus,Medline,科克伦图书馆,和WebofScience数据库,选择2004年1月至2022年12月发表的研究。公认的研究考虑了TSPO示踪剂的合成，用于痴呆和神经炎症的核医学成像。
结果：共鉴定出50篇文章。从纳入的研究文献中选择了12篇论文，排除了34篇。因此，最终选择28篇文章进行质量评估。
结论：在开发用于PET/SPECT成像的特异性和稳定的示踪剂方面已经做出了巨大的努力。18F的长半衰期使该同位素成为11C的优选选择。然而，对此的一个新的限制是神经炎症涉及所有的大脑，这抑制了检测患者轻微炎症状态变化的可能性。对此的部分解决方案是使用小脑作为参考区域并开发更高的TSPO亲和示踪剂。此外，有必要考虑造口剂和外消旋化合物的存在会干扰药理示踪剂的作用并增加图像中的噪声比。
方法：在PubMed，Scopus,Medline,科克伦图书馆,和WebofScience数据库,选择2004年1月至2022年12月发表的研究。公认的研究考虑了TSPO示踪剂的合成，用于痴呆和神经炎症的核医学成像。
结果：共鉴定出50篇文章。从纳入的研究文献中选择了12篇论文，排除了34篇。因此，最终选择28篇文章进行质量评估。
结论：在开发用于PET/SPECT成像的特异性和稳定的示踪剂方面已经做出了巨大的努力。18F的长半衰期使该同位素成为11C的优选选择。然而，对此的一个新的限制是神经炎症涉及所有的大脑，这抑制了检测患者轻微炎症状态变化的可能性。对此的部分解决方案是使用小脑作为参考区域并开发更高的TSPO亲和示踪剂。此外，有必要考虑造口剂和外消旋化合物的存在会干扰药理示踪剂的作用并增加图像中的噪声比。
