PDF(Pubmed)
Abstract：
BACKGROUND: Diabetic mastopathy is a rare breast condition that occurs in women with poorly controlled diabetes and is characterized by hardening of the breast tissue. The purpose of this case report is to provide an overview of the clinical characteristics and therapeutic principles of this rare disease to support front-line physicians in their crucial activity of case identification.
METHODS: A 64-year-old Asian female patient with a history of type II diabetes mellitus was referred to our clinic for an evaluation of a newly discovered breast mass. The patient had been diagnosed with diabetes more than 20 years prior and was being managed with oral hypoglycemic agents. Her past medical history was otherwise unremarkable. Physical examination of the breast revealed a palpable, mobile, and firm mass measuring 6 × 4 cm in the upper quadrant of the right breast. Ultrasound images showed an uneven hypoechoic nodule, BI-RADS 4B. Mammography showed the compact and flaky nature of the two breasts and the heterogeneity of the substantive density increases. The patient\'s clinical manifestations and imaging findings suggest the possibility of breast cancer. The patient opted for surgical excision of the mass. Through surgery, the mass was completely excised with negative margins. Pathological examination of the mass revealed a proliferation of fibroblastic cells, with an increased nuclear/cytoplasmic ratio, consistent with a diagnosis of diabetic mastopathy.
CONCLUSIONS: This case report serves to highlight the importance of recognizing diabetic mastopathy as a possible differential diagnosis of a breast mass in patients with diabetes mellitus. In our patient, early diagnosis and treatment with lumpectomy resulted in a favorable outcome, emphasizing the importance of prompt medical and surgical management. In addition, more research is needed to mine the diagnostic marker of diabetic mastopathy and provide data related to its prognosis.
METHODS: A 64-year-old Asian female patient with a history of type II diabetes mellitus was referred to our clinic for an evaluation of a newly discovered breast mass. The patient had been diagnosed with diabetes more than 20 years prior and was being managed with oral hypoglycemic agents. Her past medical history was otherwise unremarkable. Physical examination of the breast revealed a palpable, mobile, and firm mass measuring 6 × 4 cm in the upper quadrant of the right breast. Ultrasound images showed an uneven hypoechoic nodule, BI-RADS 4B. Mammography showed the compact and flaky nature of the two breasts and the heterogeneity of the substantive density increases. The patient\'s clinical manifestations and imaging findings suggest the possibility of breast cancer. The patient opted for surgical excision of the mass. Through surgery, the mass was completely excised with negative margins. Pathological examination of the mass revealed a proliferation of fibroblastic cells, with an increased nuclear/cytoplasmic ratio, consistent with a diagnosis of diabetic mastopathy.
CONCLUSIONS: This case report serves to highlight the importance of recognizing diabetic mastopathy as a possible differential diagnosis of a breast mass in patients with diabetes mellitus. In our patient, early diagnosis and treatment with lumpectomy resulted in a favorable outcome, emphasizing the importance of prompt medical and surgical management. In addition, more research is needed to mine the diagnostic marker of diabetic mastopathy and provide data related to its prognosis.
摘要：
背景：糖尿病性乳腺病是一种罕见的乳房疾病，发生在糖尿病控制不佳的女性中，其特征是乳房组织硬化。本病例报告的目的是概述这种罕见疾病的临床特征和治疗原则，以支持一线医师进行病例识别的关键活动。
方法：一名有II型糖尿病病史的64岁亚洲女性患者被转诊到我们的诊所评估新发现的乳腺肿块。该患者在20多年前被诊断患有糖尿病，并正在接受口服降糖药的治疗。她过去的病史在其他方面并不引人注目。乳房的体格检查显示，mobile,右乳上腹6×4cm实性肿块。超声图像显示不均匀的低回声结节，BI-RADS4B.乳房X线照相术显示两个乳房的紧凑和片状性质，并且实质性密度的异质性增加。患者的临床表现和影像学表现提示乳腺癌的可能性。患者选择手术切除肿块。通过手术,肿块完全切除,切缘阴性.肿块的病理检查显示成纤维细胞增殖，随着核/细胞质比率的增加，与糖尿病性乳腺病变的诊断一致.
结论：本病例报告强调了认识糖尿病性乳腺病作为糖尿病患者乳腺肿块的可能鉴别诊断的重要性。在我们的病人身上，乳房肿瘤切除术的早期诊断和治疗结果良好，强调及时医疗和手术管理的重要性。此外,需要更多的研究来挖掘糖尿病性乳腺病的诊断标记物,并提供与其预后相关的数据.
方法：一名有II型糖尿病病史的64岁亚洲女性患者被转诊到我们的诊所评估新发现的乳腺肿块。该患者在20多年前被诊断患有糖尿病，并正在接受口服降糖药的治疗。她过去的病史在其他方面并不引人注目。乳房的体格检查显示，mobile,右乳上腹6×4cm实性肿块。超声图像显示不均匀的低回声结节，BI-RADS4B.乳房X线照相术显示两个乳房的紧凑和片状性质，并且实质性密度的异质性增加。患者的临床表现和影像学表现提示乳腺癌的可能性。患者选择手术切除肿块。通过手术,肿块完全切除,切缘阴性.肿块的病理检查显示成纤维细胞增殖，随着核/细胞质比率的增加，与糖尿病性乳腺病变的诊断一致.
结论：本病例报告强调了认识糖尿病性乳腺病作为糖尿病患者乳腺肿块的可能鉴别诊断的重要性。在我们的病人身上，乳房肿瘤切除术的早期诊断和治疗结果良好，强调及时医疗和手术管理的重要性。此外,需要更多的研究来挖掘糖尿病性乳腺病的诊断标记物,并提供与其预后相关的数据.
