Abstract：
Coordination cages can be used for enantio- and regioselective catalysis and for the selective sensing and separation of isomeric guest molecules. Here, stereoisomers of a family of coordination cages are resolved using ultra-high-resolution cyclic ion-mobility mass spectrometry (cIM-MS). The observed ratio of diastereomers is dependent on both the metal ion and counter ion. Moreover, the point groups can be assigned through complementary NMR experiments. This method enables the identification and interrogation of the individual isomers in complex mixtures of cages which cannot be performed in solution. Furthermore, these techniques allow the stability of individual isomers within the mixture to be probed, with the T-symmetric isomers in this case shown to be more robust than the C3 and S4 analogues.
摘要：
配位笼可用于对映和区域选择性催化以及用于异构体客体分子的选择性感测和分离。这里,使用高分辨率循环离子迁移-质谱（cIM-MS）解析配位笼家族的立体异构体。观察到的非对映异构体的比例取决于金属离子和抗衡离子。此外，点组可以通过互补NMR实验进行分配。该方法能够鉴定和询问无法在溶液中进行的笼的复杂混合物中的单个异构体。此外，这些技术可以探测混合物中单个异构体的稳定性，在这种情况下，T对称异构体比C3和S4类似物更坚固。
