Abstract：
UNASSIGNED: This study was to comprehensively clarify the associations between single nucleotide polymorphisms (SNPs) in inflammatory genes and the susceptibility to childhood leukemia.
UNASSIGNED: Eligible articles were collected from the databases of PubMed, EMBASE, Cochrane Library, CNKI and Wan Fang. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimate the association strength by using the STATA 15.0 software.
UNASSIGNED: Sixteen studies were enrolled. These studies mainly evaluated SNPs in 13 genes, including C-X-C motif chemokine ligand 12 (CXCL12), toll-like receptor (TLR)-4, TLR6, TLR9, CD14, interleukin (IL)-1β, NLR family pyrin domain containing 3, IL-4, interleukin 4 receptor, IL-10, IL-13, macrophage migration inhibitory factor (MIF) and tumor necrosis factor-α. The meta-analysis indicated that CXCL12 rs1801157 (AG vs GG: OR = 1.99; 95%CI = 1.20-3.30; p = 0.008; AA + AG vs GG: OR = 1.92; 95%CI = 1.18-3.12; p = 0.009), TLR6 rs5743810 (TC vs TT: OR = 0.58; 95%CI = 0.39-0.85; p = 0.005), IL-10 rs1800871 (TC vs CC: OR = 1.19; 95%CI = 1.01-1.41; p = 0.044), rs1800872 (AC vs AA: OR = 1.53; 95%CI = 1.22-1.92; p < 0.001) and MIF rs755622 (CG versus GG: OR = 1.33; 95%CI = 1.07-1.67; p = 0.012) polymorphisms were associated with the risk of childhood leukemia. No significant correlations were found between SNPs in other genes and the childhood leukemia risk. Subgroup analyses of rs1800871 and rs1800872 confirmed the conclusions obtained in their overall meta-analytical processes.
UNASSIGNED: CXCL12 rs1801157, TLR6 rs5743810, IL-10 rs1800871, rs1800872 and MIF rs755622 polymorphisms may represent candidate biomarkers for the risk prediction of childhood leukemia.
UNASSIGNED: Eligible articles were collected from the databases of PubMed, EMBASE, Cochrane Library, CNKI and Wan Fang. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to estimate the association strength by using the STATA 15.0 software.
UNASSIGNED: Sixteen studies were enrolled. These studies mainly evaluated SNPs in 13 genes, including C-X-C motif chemokine ligand 12 (CXCL12), toll-like receptor (TLR)-4, TLR6, TLR9, CD14, interleukin (IL)-1β, NLR family pyrin domain containing 3, IL-4, interleukin 4 receptor, IL-10, IL-13, macrophage migration inhibitory factor (MIF) and tumor necrosis factor-α. The meta-analysis indicated that CXCL12 rs1801157 (AG vs GG: OR = 1.99; 95%CI = 1.20-3.30; p = 0.008; AA + AG vs GG: OR = 1.92; 95%CI = 1.18-3.12; p = 0.009), TLR6 rs5743810 (TC vs TT: OR = 0.58; 95%CI = 0.39-0.85; p = 0.005), IL-10 rs1800871 (TC vs CC: OR = 1.19; 95%CI = 1.01-1.41; p = 0.044), rs1800872 (AC vs AA: OR = 1.53; 95%CI = 1.22-1.92; p < 0.001) and MIF rs755622 (CG versus GG: OR = 1.33; 95%CI = 1.07-1.67; p = 0.012) polymorphisms were associated with the risk of childhood leukemia. No significant correlations were found between SNPs in other genes and the childhood leukemia risk. Subgroup analyses of rs1800871 and rs1800872 confirmed the conclusions obtained in their overall meta-analytical processes.
UNASSIGNED: CXCL12 rs1801157, TLR6 rs5743810, IL-10 rs1800871, rs1800872 and MIF rs755622 polymorphisms may represent candidate biomarkers for the risk prediction of childhood leukemia.
摘要：
■这项研究旨在全面阐明炎症基因中的单核苷酸多态性（SNP）与儿童白血病易感性之间的关系。
■合格的文章是从PubMed的数据库中收集的，EMBASE,科克伦图书馆,CNKI与万方通过使用STATA15.0软件计算合并比值比（ORs）和95%置信区间（95%CIs）来估计关联强度。
■共纳入16项研究。这些研究主要评估了13个基因中的SNP，包括C-X-C基序趋化因子配体12（CXCL12），toll样受体(TLR)-4、TLR6、TLR9、CD14、白细胞介素(IL)-1β、NLR家族pyrin结构域包含3、IL-4、白细胞介素4受体、IL-10，IL-13，巨噬细胞移动抑制因子（MIF）和肿瘤坏死因子-α。荟萃分析表明CXCL12rs1801157（AG与GG：OR=1.99；95CI=1.20-3.30；p=0.008；AAAG与GG：OR=1.92；95CI=1.18-3.12；p=0.009），TLR6rs5743810（TC与TT：OR=0.58；95CI=0.39-0.85；p=0.005），IL-10rs1800871（TC与CC：OR=1.19；95CI=1.01-1.41；p=0.044），rs1800872(ACvsAA:OR=1.53;95CI=1.22-1.92;p<0.001)和MIFrs755622(CGvsGG:OR=1.33;95CI=1.07-1.67;p=0.012)多态性与儿童白血病风险相关。在其他基因中的SNP与儿童白血病风险之间没有发现显着相关性。rs1800871和rs1800872的亚组分析证实了在其整体荟萃分析过程中获得的结论。
■CXCL12rs1801157、TLR6rs5743810、IL-10rs1800871、rs1800872和MIFrs755622多态性可能代表儿童白血病风险预测的候选生物标志物。
■合格的文章是从PubMed的数据库中收集的，EMBASE,科克伦图书馆,CNKI与万方通过使用STATA15.0软件计算合并比值比（ORs）和95%置信区间（95%CIs）来估计关联强度。
■共纳入16项研究。这些研究主要评估了13个基因中的SNP，包括C-X-C基序趋化因子配体12（CXCL12），toll样受体(TLR)-4、TLR6、TLR9、CD14、白细胞介素(IL)-1β、NLR家族pyrin结构域包含3、IL-4、白细胞介素4受体、IL-10，IL-13，巨噬细胞移动抑制因子（MIF）和肿瘤坏死因子-α。荟萃分析表明CXCL12rs1801157（AG与GG：OR=1.99；95CI=1.20-3.30；p=0.008；AAAG与GG：OR=1.92；95CI=1.18-3.12；p=0.009），TLR6rs5743810（TC与TT：OR=0.58；95CI=0.39-0.85；p=0.005），IL-10rs1800871（TC与CC：OR=1.19；95CI=1.01-1.41；p=0.044），rs1800872(ACvsAA:OR=1.53;95CI=1.22-1.92;p<0.001)和MIFrs755622(CGvsGG:OR=1.33;95CI=1.07-1.67;p=0.012)多态性与儿童白血病风险相关。在其他基因中的SNP与儿童白血病风险之间没有发现显着相关性。rs1800871和rs1800872的亚组分析证实了在其整体荟萃分析过程中获得的结论。
■CXCL12rs1801157、TLR6rs5743810、IL-10rs1800871、rs1800872和MIFrs755622多态性可能代表儿童白血病风险预测的候选生物标志物。
