Abstract：
Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology representing intense therapeutic challenges. It is well known that deregulation of spatiotemporally-controlled signaling pathways and their metabolic reprogramming effects play a pivotal role in the development and progression of CRC. As such, the mitochondrial role in CRC initiation gained a lot of attention recently, as it is considered the powerhouse that regulates the bioenergetics in CRC. In addition, the crosstalk between microRNAs (miRNAs) and mitochondrial dysfunction has become a newfangled passion for deciphering CRC molecular mechanisms. This review sheds light on the relationship between different signaling pathways involved in metabolic reprogramming and their therapeutic targets, alterations in mitochondrial DNA content, mitochondrial biogenesis, and mitophagy, and the role of polymorphisms in mitochondrial genes as well as miRNAs regulating mitochondrial proteins in CRC initiation, progression, metastasis, and resistance to various therapies.
摘要：
结直肠癌（CRC）是一个主要的健康问题，多因素病理生理学代表着强烈的治疗挑战。众所周知，时空控制的信号通路的失调及其代谢重编程效应在CRC的发生和发展中起关键作用。因此，线粒体在CRC启动中的作用最近获得了很多关注，因为它被认为是调节CRC中生物能学的动力。此外,microRNAs（miRNAs）与线粒体功能障碍之间的串扰已成为破译CRC分子机制的新热情。本文综述了参与代谢重编程的不同信号通路与其治疗靶点之间的关系。线粒体DNA含量的改变，线粒体生物发生，和线粒体自噬,和线粒体基因多态性的作用以及调节线粒体蛋白的miRNA在CRC起始，programming,转移,以及对各种疗法的抵制。
