PDF(Pubmed)
Abstract：
COVID-19 can affect many organ systems, including the CNS, with symptoms of altered mental status and seizures. We present a case of a 30-year-old man with cerebral palsy who developed seizures after a COVID-19 infection. Admission labs were remarkable for hypernatremia, and elevated creatine kinase, and troponin levels as well as creatinine above baseline. MRI was performed demonstrating a small, evolving acute/subacute abnormality in the midline splenium of the corpus callosum. An EEG showed moderate to severe abnormalities with low-voltage delta waves. The patient was treated with medication and advised to follow up with a neurologist. One month later, no residual CT abnormality corresponding to the previously reported lesion in the midline splenium of the corpus callosum was observed. Although epilepsy is a common finding in patients with cerebral palsy, the complete lack of seizure activity throughout this patient\'s early life, coupled with previously unremarkable brain imaging, further supports our claim that his recent onset of seizures was directly related to COVID-19. This case highlights the possibility of new seizures in patients with pre-existing neurological conditions after COVID-19 infection and emphasizes the need for more research.
摘要：
COVID-19可以影响许多器官系统，包括中枢神经系统，有精神状态改变和癫痫发作的症状。我们介绍了一例30岁的脑瘫患者，他在感染COVID-19后出现癫痫发作。入院实验室对高钠血症非常显著，和肌酸激酶升高，和肌钙蛋白水平以及肌酐高于基线。MRI显示了一个小的，call体中线脾演变为急性/亚急性异常。EEG显示中度至重度异常，低电压δ波。患者接受药物治疗，并建议接受神经科医生的随访。一个月后,未观察到与先前报告的call体中线脾病变相对应的残余CT异常。尽管癫痫在脑瘫患者中很常见，在这个病人的早期生活中完全缺乏癫痫发作活动，再加上以前平淡无奇的大脑成像，进一步支持我们的说法，即他最近的癫痫发作与COVID-19直接相关。该病例强调了COVID-19感染后已有神经系统疾病的患者可能出现新的癫痫发作，并强调需要更多的研究。
