PDF(Pubmed)
Abstract：
Mushrooms possess antihyperglycemic effect on diabetic individuals due to their nonfibrous and fibrous bioactive compounds. This study aimed to reveal the effect of different types of mushrooms on plasma glucose level and gut microbiota composition in diabetic individuals. The effects of five different mushroom species (Ganoderma lucidum, GLM; Pleurotus ostreatus, POM; Pleurotus citrinopileatus, PCM; Lentinus edodes, LEM; or Hypsizigus marmoreus, HMM) on alloxan-induced diabetic rats were investigated in this study. The results indicated that LEM and HMM treatments showed lower plasma glucose levels. For the microbiota composition, ACE, Chao1, Shannon, and Simpson were significantly affected by PCM and LEM treatments (p < .05), while ACE, Shannon, and Simpson indexes were affected by HMM treatment (p < .01). Simpson index was affected in positive control (C+) and POM groups. All these four indices were lower in GLM treatment (p < .05). Dietary supplementation of mushrooms reduced plasma glucose level directly through mushrooms\' bioactive compounds (agmatine, sphingosine, pyridoxine, linolenic, and alanine) and indirectly through stachyose (oligosaccharide) and gut microbiota modulation. In conclusion, LEM and HMM can be used as food additives to improve plasma glucose level and gut microbiome composition in diabetic individuals.
摘要：
蘑菇由于其非纤维和纤维生物活性化合物而对糖尿病个体具有抗高血糖作用。本研究旨在揭示不同类型蘑菇对糖尿病患者血浆葡萄糖水平和肠道菌群组成的影响。五种不同蘑菇种类（灵芝，GLM;平菇,POM;杏鲍菇,PCM；香菇，LEM；或者Hypsizigusmarmoreus，在这项研究中，研究了HMM）对四氧嘧啶诱导的糖尿病大鼠的影响。结果表明LEM和HMM处理显示较低的血浆葡萄糖水平。对于微生物群组成，ACE,Chao1,Shannon,和辛普森受到PCM和LEM处理的显著影响(p<0.05)，而ACE,香农,辛普森指数受HMM治疗的影响(p<0.01)。阳性对照（C）和POM组的辛普森指数受到影响。在GLM治疗中，这四个指标均较低（p<0.05）。蘑菇的膳食补充直接通过蘑菇生物活性化合物(胍丁胺，鞘氨醇,吡哆醇,亚麻酸,和丙氨酸），并间接通过水苏糖（寡糖）和肠道微生物群调节。总之,LEM和HMM可用作食品添加剂，以改善糖尿病个体的血浆葡萄糖水平和肠道微生物组组成。
