PDF(Pubmed)
Abstract：
UNASSIGNED: Behaviorally, the most pronounced effects of leptin substitution in leptin deficiency are the hunger-decreasing and postprandial satiety-prolonging effects of the adipokine. Previously, with functional magnetic resonance imaging (MRI), we and others showed that eating behavior-controlling effects are at least in part conveyed by the reward system. However, to date, it is unclear if leptin only modulates eating behavior specific brain reward action or if it also alters the reward function of the brain unrelated to eating behavior.
UNASSIGNED: We investigated with functional MRI the effects of metreleptin on the reward system in a reward task unrelated to eating behavior, the monetary incentive delay task.
UNASSIGNED: Measurements in 4 patients with the very rare disease of lipodystrophy (LD), resulting in leptin deficiency, and 3 untreated healthy control persons were performed at 4 different time points: before start and over 12 weeks of metreleptin treatment. Inside the MRI scanner, participants performed the monetary incentive delay task and brain activity during the reward receipt phase of the trial was analyzed.
UNASSIGNED: We found a reward-related brain activity decrease in our 4 patients with LD over the 12 weeks of metreleptin treatment in the subgenual region, a brain area associated with the reward network, which was not observed in our 3 untreated healthy control persons.
UNASSIGNED: These results suggest that leptin replacement in LD induces changes of brain activity during reward reception processing completely unrelated to eating behavior or food stimuli. This could suggest eating behavior-unrelated functions of leptin in the human reward system.
UNASSIGNED: The trial is registered as trial No. 147/10-ek at the ethics committee of the University of Leipzig and at the State Directorate of Saxony (Landesdirektion Sachsen).
UNASSIGNED: We investigated with functional MRI the effects of metreleptin on the reward system in a reward task unrelated to eating behavior, the monetary incentive delay task.
UNASSIGNED: Measurements in 4 patients with the very rare disease of lipodystrophy (LD), resulting in leptin deficiency, and 3 untreated healthy control persons were performed at 4 different time points: before start and over 12 weeks of metreleptin treatment. Inside the MRI scanner, participants performed the monetary incentive delay task and brain activity during the reward receipt phase of the trial was analyzed.
UNASSIGNED: We found a reward-related brain activity decrease in our 4 patients with LD over the 12 weeks of metreleptin treatment in the subgenual region, a brain area associated with the reward network, which was not observed in our 3 untreated healthy control persons.
UNASSIGNED: These results suggest that leptin replacement in LD induces changes of brain activity during reward reception processing completely unrelated to eating behavior or food stimuli. This could suggest eating behavior-unrelated functions of leptin in the human reward system.
UNASSIGNED: The trial is registered as trial No. 147/10-ek at the ethics committee of the University of Leipzig and at the State Directorate of Saxony (Landesdirektion Sachsen).
摘要：
■行为，瘦素替代在瘦素缺乏症中最明显的作用是脂肪因子的饥饿减少和餐后饱腹感延长作用。以前,功能磁共振成像（MRI），我们和其他人表明，饮食行为控制效果至少部分由奖励系统传达。然而,到目前为止,目前尚不清楚瘦素是否仅调节进食行为特定的大脑奖励作用，或者是否也改变了与进食行为无关的大脑奖励功能。
■我们使用功能性MRI研究了metreleptin在与进食行为无关的奖励任务中对奖励系统的影响，货币激励延迟任务。
■对4例非常罕见的脂肪营养不良（LD）患者的测量，导致瘦素缺乏，和3名未经治疗的健康对照者在4个不同的时间点进行：开始前和超过12周的metreleptin治疗。在核磁共振扫描仪里面,参与者执行了货币激励延迟任务,并分析了试验获得奖励阶段的大脑活动.
■我们发现，在接受metreleptin治疗的12周内，我们的4名LD患者在亚基因区出现了与奖励相关的脑活动减少，与奖励网络相关的大脑区域，这在我们的3名未经治疗的健康对照人中没有观察到。
■这些结果表明，LD中的瘦素替代会在与进食行为或食物刺激完全无关的奖励接收过程中引起大脑活动的变化。这可能表明瘦素在人类奖励系统中的饮食行为无关功能。
■该试验注册为试验编号。147/10-ek在莱比锡大学道德委员会和萨克森州总局（LandesdirektionSachsen）。
■我们使用功能性MRI研究了metreleptin在与进食行为无关的奖励任务中对奖励系统的影响，货币激励延迟任务。
■对4例非常罕见的脂肪营养不良（LD）患者的测量，导致瘦素缺乏，和3名未经治疗的健康对照者在4个不同的时间点进行：开始前和超过12周的metreleptin治疗。在核磁共振扫描仪里面,参与者执行了货币激励延迟任务,并分析了试验获得奖励阶段的大脑活动.
■我们发现，在接受metreleptin治疗的12周内，我们的4名LD患者在亚基因区出现了与奖励相关的脑活动减少，与奖励网络相关的大脑区域，这在我们的3名未经治疗的健康对照人中没有观察到。
■这些结果表明，LD中的瘦素替代会在与进食行为或食物刺激完全无关的奖励接收过程中引起大脑活动的变化。这可能表明瘦素在人类奖励系统中的饮食行为无关功能。
■该试验注册为试验编号。147/10-ek在莱比锡大学道德委员会和萨克森州总局（LandesdirektionSachsen）。
