PDF(Pubmed)
Abstract：
Neurolymphomatosis is rarely encountered in high-grade lymphomas. In this case series, we retrospectively analyzed six neurolymphomatosis cases to look for possible risk factors, common and uncommon presentations, and the lessons learned. Neuropathic pain was the most common symptom with mono or polyradiculopathy in this series. However, all lymphomatous infiltrated nerves diagnosed on fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) were not symptomatic. The lumbar, brachial plexus, and trigeminal nerve were the most common sites and were depicted well on FDG PET/CT. Magnetic resonance imaging (MRI) of the brain better delineates cranial nerves and meningeal involvement. Cerebrospinal fluid flow cytometry was normal until meninges were involved. FDG PET/CT incrementally evaluated extra-neural disease sites, thus helping in deciding biopsy sites and further management. We concluded that a whole-body FDG PET/CT including limbs with MRI brain was the appropriate investigation for evaluating suspected neurolymphomatosis in advanced-stage diffuse large B-cell lymphoma.
摘要：
在高级别淋巴瘤中很少遇到神经淋巴瘤病。在这个系列中,我们回顾性分析了6例神经淋巴瘤病例，以寻找可能的危险因素，常见和不常见的演示文稿，和吸取的教训。在该系列中，神经性疼痛是单发或多神经根病最常见的症状。然而,氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描(FDGPET/CT)诊断的所有淋巴瘤浸润神经均无症状.腰部，臂丛神经,和三叉神经是最常见的部位，在FDGPET/CT上表现良好。大脑的磁共振成像（MRI）可以更好地描绘颅神经和脑膜受累。脑脊液流式细胞术正常，直到累及脑膜。FDGPET/CT增量评估神经外疾病部位，从而有助于确定活检部位和进一步的管理。我们得出的结论是，全身FDGPET/CT包括四肢和MRI大脑是评估晚期弥漫性大B细胞淋巴瘤中可疑神经淋巴瘤病的适当研究。
