PDF(Pubmed)
Abstract：
The tumor necrosis factor superfamily (TNFSF) and their receptors (TNFRSF) are important regulators of the immune system, mediating proliferation, survival, differentiation, and function of immune cells. As a result, their targeting for immunotherapy is attractive, although to date, under-exploited. In this review we discuss the importance of co-stimulatory members of the TNFRSF in optimal immune response generation, the rationale behind targeting these receptors for immunotherapy, the success of targeting them in pre-clinical studies and the challenges in translating this success into the clinic. The efficacy and limitations of the currently available agents are discussed alongside the development of next generation immunostimulatory agents designed to overcome current issues, and capitalize on this receptor class to deliver potent, durable and safe drugs for patients.
摘要：
肿瘤坏死因子超家族(TNFSF)及其受体(TNFRSF)是免疫系统的重要调节因子,介导增殖，生存,分化,和免疫细胞的功能。因此,它们的靶向免疫疗法很有吸引力，虽然到目前为止,开发不足。在这篇综述中，我们讨论了TNFRSF的共刺激成员在最佳免疫应答产生中的重要性，靶向这些受体进行免疫治疗的基本原理，在临床前研究中成功靶向它们，以及将这种成功转化为临床的挑战。讨论了当前可用药物的功效和局限性，以及旨在克服当前问题的下一代免疫刺激剂的开发。并利用这种受体类来提供有效的，持久和安全的药物为患者。
