Abstract：
Chronic pruritus (CP) (ie, itch that persists for more than 6 weeks) poses significant challenges to patients\' health and quality of life. It is a common reason for visits to dermatologists and general practitioners and can be caused by a range of conditions, including systemic diseases such as chronic kidney disease or liver diseases, malignancies, neuropathic conditions, and dermatoses such as atopic dermatitis. CP often does not develop in parallel with the course of the disease and can become an entity of its own, which must be treated with antipruritic drugs, even if the underlying cause is already under therapy. Depending on the etiology of CP, different pathways in the pathogenesis have been analyzed recently, following which new treatments have been developed and tested in randomized controlled trials. This article discusses the recent results of these studies and highlights how best to manage health care for patients with CP.
摘要：
慢性瘙痒,瘙痒持续超过六周，对患者的健康和生活质量构成重大挑战。这是访问皮肤科医生和全科医生的常见原因，可能是由一系列条件引起的，包括慢性肾病或肝病等全身性疾病，恶性肿瘤,以及神经病症和皮肤病，如特应性皮炎。慢性瘙痒通常不会与疾病的过程平行发展，并且可以成为其自身的实体，必须止痒治疗，即使根本原因已经在治疗中。根据慢性瘙痒的病因，最近已经分析了发病机理中的不同途径，随后开发了新的治疗方法,并在随机对照试验中进行了测试.本文讨论了这些研究的最新结果，并重点介绍了如何最好地管理慢性瘙痒患者的医疗保健。
