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Abstract：
Frontal sinus involvement by malignant tumors is a rare finding. Therefore, a systematic literature review along with a personal case series may contribute to defining more accurately the epidemiology, treatment options, and outcomes of these neoplasms. This is a retrospective review of patients affected by frontal sinus malignancies surgically treated in a tertiary-care referral center over a period of 20 years. Moreover, a systematic literature review of studies describing frontal sinus cancers from 2000 to date was performed according to PRISMA guidelines in order to analyze current evidence about the treatment and outcomes of such a rare disease. Our retrospective review was basedon 84 cases, treated with an exclusive endoscopic approach in 43 cases (51.2%), endoscopic approach with frontal osteoplastic flap in 6 cases (7.1%), and transfacial or transcranial approaches in 35 cases (41.7%). The five-year overall, disease-specific, disease-free, and recurrence-free survivals were 54.6%, 62.6%, 33.1%, and 59.1%, respectively. Age, dural involvement, type of surgical resection, and surgical margin status were significantly associated with the survival endpoints. In conclusion, the involvement of the frontal sinus is associated with a poor prognosis. Multidisciplinary management, including specific histology-driven treatments, represents the gold standard for improving outcomes and minimizing morbidity.
摘要：
恶性肿瘤累及额窦是一个罕见的发现。因此,系统的文献综述以及个人病例系列可能有助于更准确地定义流行病学，治疗方案,以及这些肿瘤的结果。这是一项回顾性研究，对在三级护理转诊中心接受手术治疗的额窦恶性肿瘤患者进行了20年的回顾性研究。此外，我们根据PRISMA指南对2000年至今描述额窦癌的研究进行了系统的文献综述,以分析目前关于这种罕见疾病的治疗和结局的证据.我们的回顾性研究以84例病例为基础，43例（51.2%），内镜下经额骨增生皮瓣入路6例(7.1%),经面或经颅入路35例(41.7%)。整个五年，疾病特异性,无病,无复发生存率为54.6%,62.6%,33.1%,和59.1%，分别。年龄,硬脑膜受累,手术切除的类型，手术切缘状态与生存终点显著相关.总之,额窦受累与预后不良相关.多学科管理,包括特定的组织学驱动的治疗，代表改善结果和最小化发病率的黄金标准。
