PDF(Pubmed)
Abstract：
The human bladder has been long thought to be sterile until that, only in the last decade, advances in molecular biology have shown that the human urinary tract is populated with microorganisms. The relationship between the urobiota and the development of urinary tract disorders is now of great interest. Patients with spina bifida (SB) can be born with (or develop over time) neurological deficits due to damaged nerves that originate in the lower part of the spinal cord, including the neurogenic bladder. This condition represents a predisposing factor for urinary tract infections so that the most frequently used approach to treat patients with neurogenic bladder is based on clean intermittent catheterization (CIC). In this study, we analyzed the urobiota composition in a pediatric cohort of patients with SB compared to healthy controls, as well as the urobiota characteristics based on whether patients received CIC or not.
摘要：
长期以来，人们一直认为人类膀胱是无菌的，只有在过去的十年里，分子生物学的进展表明，人类泌尿道中充满了微生物。尿路生物群与泌尿道疾病发展之间的关系现在引起了极大的兴趣。脊柱裂（SB）患者可能由于起源于脊髓下部的受损神经而出生（或随时间发展）神经功能缺损，包括神经源性膀胱.这种情况是尿路感染的诱发因素，因此治疗神经源性膀胱患者最常用的方法是基于清洁间歇性导管插入术（CIC）。在这项研究中,我们分析了SB患者与健康对照的儿科队列中的尿群组成，以及基于患者是否接受CIC的尿路生物群特征。
