PDF(Pubmed)
Abstract：
Paxillin is a multi-domain adaptor protein. As an important member of focal adhesion (FA) and a participant in regulating cell movement, paxillin plays an important role in physiological processes such as nervous system development, embryonic development, and vascular development. However, increasing evidence suggests that paxillin is aberrantly expressed in many cancers. Many scholars have also recognized that the abnormal expression of paxillin is related to the prognosis, metastases, invasion, survival, angiogenesis, and other aspects of malignant tumors, suggesting that paxillin may be a potential cancer therapeutic target. Therefore, the study of how aberrant paxillin expression affects the process of tumorigenesis and metastasis will help to develop more efficacious antitumor drugs. Herein, we review the structure of paxillin and its function and expression in tumors, paying special attention to the multifaceted effects of paxillin on tumors, the mechanism of tumorigenesis and progression, and its potential role in tumor therapy. We also hope to provide a reference for the clinical prognosis and development of new tumor therapeutic targets.
摘要：
Paxillin是一种多结构域衔接蛋白。作为局灶性粘连（FA）的重要成员和调节细胞运动的参与者，paxillin在神经系统发育等生理过程中起着重要作用，胚胎发育,和血管发育。然而,越来越多的证据表明，paxillin在许多癌症中异常表达。许多学者也认识到paxillin的异常表达与预后有关，转移,入侵,生存,血管生成,和其他方面的恶性肿瘤，表明paxillin可能是一个潜在的癌症治疗靶点。因此,研究paxillin的异常表达如何影响肿瘤发生和转移过程，将有助于开发更有效的抗肿瘤药物。在这里，我们综述了paxillin的结构及其在肿瘤中的功能和表达,特别关注Paxillin对肿瘤的多方面影响，肿瘤发生和发展的机制，及其在肿瘤治疗中的潜在作用。我们也希望为临床预后和开发新的肿瘤治疗靶点提供参考。
