PDF(Pubmed)
Abstract：
Ferulic acid (FA), a prevalent dietary phytochemical, has many pharmacological effects, including anti-oxidation and anti-inflammation effects, and has been widely used in the pharmaceutical, food, and cosmetics industries. Many studies have shown that FA can significantly downregulate the expression of reactive oxygen species and activate nuclear factor erythroid-2-related factor-2/heme oxygenase-1 signaling, exerting anti-oxidative effects. The anti-inflammatory effect of FA is mainly related to the p38 mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways. FA has demonstrated potential clinical applications in the treatment of pulmonary diseases. The transforming growth factor-β1/small mothers against decapentaplegic 3 signaling pathway can be blocked by FA, thereby alleviating pulmonary fibrosis. Moreover, in the context of asthma, the T helper cell 1/2 imbalance is restored by FA. Furthermore, FA ameliorates acute lung injury by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase pathways via toll-like receptor 4, consequently decreasing the expression of downstream inflammatory mediators. Additionally, there is a moderate neuraminidase inhibitory activity showing a tendency to reduce the interleukin-8 level in response to influenza virus infections. Although the application of FA has broad prospects, more preclinical mechanism-based research should be carried out to test these applications in clinical settings. This review not only covers the literature on the pharmacological effects and mechanisms of FA, but also discusses the therapeutic role and toxicology of FA in several pulmonary diseases.
摘要：
阿魏酸(FA),一种普遍的饮食植物化学物质，有许多药理作用，包括抗氧化和抗炎作用,并已广泛用于制药，食物,和化妆品行业。许多研究表明，FA可以显著下调活性氧的表达，激活核因子-2相关因子-2/血红素加氧酶-1信号，发挥抗氧化作用。FA的抗炎作用主要与p38丝裂原活化蛋白激酶和核因子-κB信号通路有关。FA已在肺部疾病的治疗中显示出潜在的临床应用。转化生长因子-β1/小母鼠抗十指截瘫3信号通路可被FA阻断,从而减轻肺纤维化。此外，在哮喘的背景下，T辅助细胞1/2失衡通过FA恢复。此外，FA通过Toll样受体4抑制核因子-κB和丝裂原激活的蛋白激酶途径改善急性肺损伤，从而降低下游炎症介质的表达。此外,有中等的神经氨酸酶抑制活性，显示出在对流感病毒感染的反应中降低白细胞介素-8水平的趋势。虽然FA的应用前景广阔,应开展更多基于临床前机制的研究,以测试这些在临床环境中的应用.这篇综述不仅涵盖了有关FA的药理作用和机制的文献，还讨论了FA在几种肺部疾病中的治疗作用和毒理学。
