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Abstract：
The World Health Organization has identified oncological diseases as one of the most serious health concerns of the current century. Current research on oncogenesis is focused on the molecular mechanisms of energy-biochemical reprogramming in cancer cell metabolism, including processes contributing to the Warburg effect and the pro-oncogenic and anti-oncogenic roles of sirtuins (SIRTs) and poly-(ADP-ribose) polymerases (PARPs). However, a clear understanding of the interaction between NAD+, SIRTs in cancer development, as well as their effects on carcinogenesis, has not been established, and literature data vary greatly. This work aims to provide a summary and structure of the available information on NAD+, SIRTs interactions in both stimulating and countering carcinogenesis, and to discuss potential approaches for pharmacological modulation of these interactions to achieve an anticancer effect.
摘要：
世界卫生组织已将肿瘤疾病确定为本世纪最严重的健康问题之一。当前关于肿瘤发生的研究集中在细胞代谢的能量-生化重编程的分子机制上，包括促成Warburg效应的过程以及沉默调节蛋白（SIRTs）和聚（ADP-核糖）聚合酶（PARP）的促致癌和抗肿瘤作用。然而,清楚了解NAD+之间的相互作用，SIRTs在癌症发展中，以及它们对致癌作用的影响，尚未建立，文献数据差异很大。这项工作旨在提供有关NAD+的可用信息的摘要和结构，SIRTs在刺激和对抗致癌作用中的相互作用，并讨论药理调节这些相互作用以实现抗癌作用的潜在方法。
